2012 Fiscal Year Final Research Report
The role of beta 7 integrin on cutaneous cell infiltration and melanoma
| Project/Area Number |
22591217
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Shinichi 東京大学, 医学部附属病院, 教授 (20215792)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 皮膚腫瘍学 |
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| Research Abstract |
As leukocyte infiltration is one of the most important factors for tumor immunity in melanoma, we investigated the role of beta 7 integrin and alpha E integrin that belong to adhesion molecules implicated in leukocyte migration. The lack of alpha E integrin did not affect tumor immunity, whereas beta 7 integrin deficiency significantly augmented the tumor immunity. When beta 7 integrin is deficient, the expressions of ICAM-1 and VCAM-1 were upregulated to compensate for the loss of beta 7 integrin, which lead to the increase of Th1-type CD4-positive T cells which produced significant amount of interferon gamma.
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