Application of Serum Antibodies against c-myc to Malignant Solid Tumors

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591416
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Toho University
• Principal Investigator: YAMAZAKI Kunihiro 東邦大学, 医学部, 客員講師 (00307761)
• Co-Investigator(Kenkyū-buntansha): SHIMADA Hideaki 東邦大学, 医学部, 教授 (20292691)
• Project Period (FY): 2010 – 2012
• Keywords: SEREX / serum antibody / c-myc / malignant tumor

Research Abstract

Purpose of this study was (i) establish ELISA system to detect serum anti-c-myc antibodies, and (ii) evaluate positive rate of serum anti-c-myc antibodies in patients with malignant solid tumors. Using a cut-off value of mean +3SD of serum anti-c-myc antibody level of healthy controls, positive rate of patients were evaluated. Various kind of serum samples from stage I or stage II cancer patients were analyzed for serum c-myc antibodies. The positive rates were prostae cancer=8%, lung cancer=9%, gastric cancer=14%, colon cancer=6%, breastcancer=13%, esophageal cancer=12%, liver cancer=10%, respectively. No clinicopathological factors were associated with presence of anti-c-myc antibodies. Plural serum antibodiescan increase sensitivity to detect cancer.

Research Products

• [Journal Article] SAP155-mediated c-myc suppressor FBP-interacting repressor splicing variants are activated in colon cancer tissues (2013)
  • Author(s): Kajiwara T, Matsushita K, Itoga S, Tamura M, Tanaka N, Tomonaga T, Matsubara H, Shimada H, Habara Y, Matsuo M, Nomura F
  • Journal Title: Cancer Sci Volume: 104(2) Pages: 149-156.
  • DOI: DOI:10.1111/cas.12058
  • Peer Reviewed
• [Journal Article] Impact of serum biomarkers on esophageal squamous cell carcinoma (2012)
  • Author(s): Shimada H, Yajima S, Oshima Y, Hiwasa T, Tagawa M, Matsushita K, Nomura F
  • Journal Title: Esophagus Volume: 9(3) Pages: 131-140.
  • DOI: DOI:10.1007/s10388-012-0332-x
  • Peer Reviewed
• [Journal Article] SAP155-mediated splicing of FUSE-binding protein-interacting repressor (FIR) serves as a molecular switch for c-myc gene expression. Molecular cancer research (2012)
  • Author(s): Matsushita K, Kajiwara T, Tamura M, Satoh M, Tanaka N, Tomonaga T, Matsubara H, Shimada H, Yoshimoto R, Ito A, Kubo S, Natsume T, Levens D, Yo shi da M, No mur a F
  • Journal Title: MCR Volume: 10(6) Pages: 787-799.
  • DOI: DOI:10.1158/1541-7786.MCR-11-0462
  • Peer Reviewed
• [Journal Article] Upregulated p53 expression activates apoptotic pathways in wild-type p53-bearing mesothelioma and enhances cytotoxicity of cisplatin and pemetrexed (2012)
  • Author(s): Li Q, Kawamura K, Yamanaka M, Okamoto S, Yang S, Yamauchi S, Fukamachi T, Kobayashi H, Tada Y, Takiguchi Y, Tatsumi K, Shimada H, Hiroshima K, Tagawa M
  • Journal Title: Cancer Gene Ther Volume: 19(3) Pages: 218-228.
  • DOI: DOI:10.1038/cgt.2011.86.
  • Peer Reviewed
• [Journal Article] Adhesion molecule periplakin is involved in cellular movement and attachment in pharyngeal squamous cancer cells (2011)
  • Author(s): Tonoi ke Y, Matsushi ta K, Tomonaga T, Katada K, Tanaka N, Shimada H, Na ka t ani Y, Oka mo t o Y, No mur a F
  • Journal Title: BMC cell biol Volume: 12(1) Pages: 41.
  • DOI: DOI:10.1186/1471-2121-12-41
  • Peer Reviewed
• [Journal Article] Synergistic effect of non-transmissible Sendai virus vector encoding the c-myc suppressor FUSE-binding protein-interacting repressor plus cisplatin in the treatment of malignant pleural mesothelioma (2011)
  • Author(s): Kitamura A, Matsushita K, Takiguchi Y, Shimada H, Tada Y, Yamanaka M, Hiroshima K, Tagawa M, Tomonaga T, Matsubara H, Inoue M, Hasegawa M, Sato Y, Levens D, Tatsumi K, Nomura F
  • Journal Title: Cancer Sci Volume: 102(7) Pages: 1366-1373.
  • DOI: DOI:10.1111/j.1349-7006.2011.01931.x.
  • Peer Reviewed
• [Presentation] 食道扁平上皮癌の血液バイオマーカーの開発 (2012)
  • Author(s): 島田英昭
  • Organizer: 第64回日本気管食道科学会総会ならびに学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2012-11-09
• [Presentation] 島田英昭, 谷島 聡, 小池淳一, 田川雅敏, 竹田明彦, 松下一之, 日和佐隆樹, 野村文夫 (2011)
  • Author(s): 島田英昭, 谷島 聡, 小池淳一, 田川雅敏, 竹田明彦, 松下一之, 日和佐隆樹, 野村文夫
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-05
• [Presentation] 消化器癌症例における血清SEREX抗体の検出～新しいバイオマーカー検査法開発を目指して～ (2011)
  • Author(s): 谷島 聡, 島田英昭, 山崎有浩, 大嶋陽幸, 鈴木 隆, 名波竜規, 石井 淳, 大塚由一郎, 鷲澤尚宏, 金子弘真
  • Organizer: 第66回日本消化器外科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-07-14
• [Presentation] Serum SEREX antibodies as new biomarkers for gastric cancer (2011)
  • Author(s): Shimada H, Ya ma za ki K, Yajima S, Oshima Y, Nanami T, Tamura A, Kaneko H
  • Organizer: 9th International Gastric Cancer Congress Seoul
  • Place of Presentation: Korea
  • Year and Date: 2011-04-21