2012 Fiscal Year Final Research Report
The efficacy of blood biomarkers in acute or sub-acute spinal cord injury
| Project/Area Number |
22591649
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | National Rehabilitation Center for Persons with Disabilities |
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Principal Investigator |
TOBIMATSU Yoshiko 国立障害者リハビリテーションセンター(研究所), 研究所 義肢装具技術研究部, 部長 (20172174)
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| Co-Investigator(Kenkyū-buntansha) |
OGATA Toru 国立障害者リハビリテーションセンター(研究所), 研究所運動機能系障害研究部, 部長 (00392192)
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| Project Period (FY) |
2010 – 2012
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| Keywords | バイオマーカー / 軸索損傷 / ヒト脊髄損傷 / ELISA |
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| Research Abstract |
To assess the efficacy of plasma pNF-H as a biomarker of axonal injury, we performed a pilot cross-sectional study of patients with acute cervical spinal cord injury (SCI). The pNF-H assay was carried out with a commercially available ELISA kit. Plasma pNF-H was elevated in accordance with the severity of SCI and reflected a greater magnitude of axonal damage. Therefore, pNF-H is a potential biomarker to independently distinguish AIS A patients (complete SCI) from AIS C-E patients (incomplete SCI).
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