2012 Fiscal Year Final Research Report
Association between single nucleotide polymorphism of beta2-Adrenergic receptor gene and pelvic floor muscle function in POP and/or SUI patients
| Project/Area Number |
22591795
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIBASHI Kei 福島県立医科大学, 医学部, 講師 (90347211)
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| Co-Investigator(Renkei-kenkyūsha) |
NOMIYA Masanori 福島県立医科大学, 医学部, 助教 (00398348)
TAKAHASHI Norio 福島県立医科大学, 医学部, 助教 (50622312)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ss2 受容体 / 女性骨盤底 / 遺伝子多型 / 骨盤底筋 |
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| Research Abstract |
Patients with pelvic organ prolapse (POP) and/or stress urinaryincontinence have lower pelvic floor muscle (PFM) function. We hypothesized that single nucleotide polymorphism of beta 2-Adrenergic receptor gene could be associated with pelvic floor muscle function. We have developed our original system which can record the intra-vaginal pressure by touch sensor array and PFM movement by evaluation using an intravaginal probe. We have also established the methods which can detect single nucleotide polymorphism of beta 2-Adrenergic receptor gene by TaqMan methods using real time PCR. Further studies with number of POP and/or SUI cases are required to confirm ourhypothesis.
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