2011 Fiscal Year Final Research Report
Molecular Epidemiological Studies using Helicobacter pylori
| Project/Area Number |
22659087
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAITOU Naruya 国立遺伝学研究所, 教授 (30192587)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ピロリ菌 / 分子疫学 / 起源 / 沖縄 |
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| Research Abstract |
In this study, we extracted the DNA from Helicobacter pylori isolated in Okinawa, and performed the genotypes of virulence factors(cagA and vacA) and multilocus sequence typing using 7 housekeeping genes. Low prevalence of gastric cancer in Okinawa may result from the high prevalence of low virulent strains(Western-type cagA and cagA-negative strains, vacA s2m2 type). The origin of these strains in Okinawa may be different from those of Western countries, and these strains in Okinawa might evolve independently.
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[Journal Article] Clinical relevance of cagPAI intactness in Helicobacter pylori isolates from Vietnam2010
Author(s)
Nguyen LT, Uchida T, Tsukamoto Y, Trinh TD, Ta L, Mai HB, Le HS, Ho DQ, Hoang HH, Matsuhisa T, Okimoto T, Kodama M, Murakami K, Fujioka T, Yamaoka Y, Moriyama M
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Journal Title
Eur J Clin Microbiol Infect Dis
Volume: 29
Pages: 651-60
Peer Reviewed
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