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2013 Fiscal Year Final Research Report

Development of statistical methods utilizing longitudinal data and time to event data effectively.

Research Project

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Project/Area Number 22700297
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Statistical science
Research InstitutionKurume University

Principal Investigator

YONEMOTO Koji  久留米大学, バイオ統計センター, 講師 (90398090)

Project Period (FY) 2010-04-01 – 2014-03-31
Keywords同時モデリング / 非線形 / 縮小ランク回帰法 / 疫学 / 生存時間データ / 栄養疫学 / 経時データ
Research Abstract

For effect of risk factors on development of diseases, we proposed a modeling algorithm which can detect nonlinearity of the effect and confirmed performance of it by a simulation study. We showed that using joint modeling can reduce effect of regression dilution bias, i.e., joint modeling may be useful for observational studies. In nutrition epidemiology, variability of dietary patterns extracted by using reduced rank regression with biomarkers is large so generalizability of the pattern may be problematic. Moreover, we conducted many epidemiological studies, and many papers were published in international journals.

  • Research Products

    (32 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (20 results) (of which Peer Reviewed: 19 results) Presentation (12 results)

  • [Journal Article] Serum 1,25-dihydroxyvitamin D and the development of kidney dysfunction in a Japanese community : the Hisayama Study2014

    • Author(s)
      Izumaru K., Ninomiya T., Nagata M., 他7名
    • Journal Title

      Circulation Journal

      Volume: 78 Pages: 732-737

    • DOI

      10.1253/circj.CJ-13-0422

    • Peer Reviewed
  • [Journal Article] Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men : a cross-sectional study2013

    • Author(s)
      Sekita A., Arima H., Ninomiya T., 他10名
    • Journal Title

      BMC Public Health

      Volume: 13 Pages: 862

    • DOI

      10.1186/1471-2458-13-862

    • Peer Reviewed
  • [Journal Article] RECQL1 DNA Repair Helicase : A Potential Therapeutic Target and a Proliferative Marker against Ovarian Cancer2013

    • Author(s)
      Sanada S., Futami K., Terada A., 他9名
    • Journal Title

      Plos One

      Volume: Volume8, 8 Pages: 1-8

    • DOI

      10.1371/journal.pone.0072820

    • Peer Reviewed
  • [Journal Article] A Phase II study of personalized peptide vaccination for chemotherapy-resistant advanced pancreatic cancer patients2013

    • Author(s)
      Yutani S., Komatsu N., Yoshitomi M., 他8名
    • Journal Title

      Oncology Report

      Volume: 30 Pages: 1094-1100

    • DOI

      10.3892/or.2013.2556

    • Peer Reviewed
  • [Journal Article] White-Coat and Masked Hypertension Are Associated With Carotid Atherosclerosis in a General Population : The Hisayama Study2013

    • Author(s)
      Fukuhara M., Arima H., Ninomiya T., 他10名
    • Journal Title

      Stroke

      Volume: 44 Pages: 1512-1517

    • DOI

      10.1161/STROKEAHA.111.000704

    • Peer Reviewed
  • [Journal Article] Secular trends in cardiovascular disease and its risk factors in Japanese : half century data from the Hisayama Study, 1961-20092013

    • Author(s)
      Hata J., Ninomiya T., Hirakawa Y., 他11名
    • Journal Title

      Circulation

      Volume: 128 Pages: 1198-1205

    • DOI

      10.1161/CIRCULATIONAHA.113.002424

    • Peer Reviewed
  • [Journal Article] Dietary patterns and risk of dementia in an elderly Japanese population : the Hisayama Study2013

    • Author(s)
      Ozawa M., Ninomiya T., Ohara T., 他6名
    • Journal Title

      The American Journal of Clinical Nutrition

      Volume: 97 Pages: 1076-1082

    • DOI

      10.3945/ajcn.112.045575

    • Peer Reviewed
  • [Journal Article] Hypoalbuminemia and lymphocytopenia are predictive risk factors for in-hospital mortality in patients with tuberculosis2013

    • Author(s)
      Okamura K., Nagata N., Wakamatsu K., 他5名
    • Journal Title

      Internal Medicine

      Volume: 52 Pages: 439-444

    • DOI

      10.2169/internalmedicine.52.8158

    • Peer Reviewed
  • [Journal Article] Normative Data for the Montreal Cognitive Assessment in a Japanese Community-Dwelling Older Population2013

    • Author(s)
      Narazaki K., Nofuji Y., Honda T., 他3名
    • Journal Title

      Neuroepidemiology

      Volume: 40 Pages: 23-29

    • DOI

      10.1159/000339753

    • Peer Reviewed
  • [Journal Article] Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence : the Hisayama Study2012

    • Author(s)
      Shikata K., Ninomiya T., Yonemoto K., 他8名
    • Journal Title

      Scandinavian Journal of Gastroenterology

      Volume: 47(6) Pages: 669-675

    • DOI

      10.3109/00365521.2012.658855

    • Peer Reviewed
  • [Journal Article] Serum IgG4 was Associated with the number and the distribution of the extrapancreatic lesions in type 1 Autoimmune Pancreatitis Patients2012

    • Author(s)
      Kaji R., Takedatsu H., Okabe Y., 他6名
    • Journal Title

      Journal of gastroenterology and hepatology

      Volume: vol27, issue2 Pages: 268-272

    • DOI

      10.1111/j.1440-1746.2011.06933.x

    • Peer Reviewed
  • [Journal Article] Comparative study of vitrectomy versus intravitreous triamcinolone for diabetic macular edema on randomized paired-eyes2012

    • Author(s)
      Doi N., Sakamoto T., Sonoda Y., 他4名
    • Journal Title

      GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

      Volume: 250 Pages: 71-78

    • DOI

      10.1007/s00417-011-1777-7

    • Peer Reviewed
  • [Journal Article] A new vasculitis activity score for predicting death in myeloperoxidase-antineutrophil cytoplasmic antibody associated vasculitis patients2012

    • Author(s)
      Koike K., Fukami K., Yonemoto K., 他9名
    • Journal Title

      American Journal of Nephrology

      Volume: 35 Pages: 1-6

    • DOI

      10.1159/000334357

    • Peer Reviewed
  • [Journal Article] Impact of Lower Range of Prehypertension on Cardiovascular Events in a General Population : the Hisayama Study2012

    • Author(s)
      Fukuhara M., Arima H., Ninomiya T., 他7名
    • Journal Title

      Journal of Hypertension

      Volume: 30 Pages: 893-900

    • DOI

      10.1097/HJH.0b013e328351d380

    • Peer Reviewed
  • [Journal Article] Body mass index and stroke incidence in a Japanese community : the Hisayama study2011

    • Author(s)
      Yonemoto K.,Doi Y., Hata J., 他6名
    • Journal Title

      Hypertension Research

      Volume: 34 Pages: 274-279

    • DOI

      10.1038/hr.2010.220

    • Peer Reviewed
  • [Journal Article] High serum bilirubin levels and diabetic retinopathy the Hisayama Study2011

    • Author(s)
      Yasuda M., Kiyohara W., Wang JJ., 他5名
    • Journal Title

      Ophthalmology

      Volume: 118 Pages: 1423-1428

    • DOI

      10.1016/j.ophtha.2010.12.009

    • Peer Reviewed
  • [Journal Article] Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community : the Hisayama Study2010

    • Author(s)
      Sekita A., Ninomiya T., Tanizaki Y., 他9名
    • Journal Title

      ACTA PSYCHIATRICA SCANDINAVICA

      Volume: 122 Pages: 319-325

    • DOI

      10.1111/j.1600-0447.2010.01587.x

    • Peer Reviewed
  • [Journal Article] QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population : the Hisayama Study2010

    • Author(s)
      Maebuchi D., Arima H., Doi Y., 他8名
    • Journal Title

      Hypertens Research

      Volume: 33 Pages: 916-921

    • DOI

      10.1038/hr.2010.88

    • Peer Reviewed
  • [Journal Article] Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population2010

    • Author(s)
      Matsushita T., Umeno J. Hirakawa Y., 他11名
    • Journal Title

      Journal of Human Genetics

      Volume: 55 Pages: 473-476

    • DOI

      10.1038/jhg.2010.45

    • Peer Reviewed
  • [Journal Article] White Blood Cell Count and Risk of Gastric Cancer Incidence in a General Japanese Population: the Hisayama Study

    • Author(s)
      Iida M., Ikeda F., Ninomiya T., 他6名
    • DOI

      10.1093/aje/kwr345

  • [Presentation] 地域在住高齢者における臨床前認知機能マーカーとしての体力指標の可能性2013

    • Author(s)
      楢崎兼司
    • Organizer
      運動疫学研究会
    • Place of Presentation
      国立健康・栄養研究所
    • Year and Date
      2013-09-20
  • [Presentation] BKV サブタイプ3 型が同種造血幹細胞移植後出血性膀胱炎の発症リスクである : 福岡骨髄移植グループ(FBMTG)の検討2013

    • Author(s)
      加藤光次
    • Organizer
      日本造血細胞移植学会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2013-03-09
  • [Presentation] 骨髄腫細胞で検出される遺伝子変異の臨床的意義(JSCT-MM05 付随研究)2013

    • Author(s)
      角南一貴
    • Organizer
      日本造血細胞移植学会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2013-03-08
  • [Presentation] BK Virus Subtype III Is Associated with Hemorrhagic Cystitis After Allogeneic Hematopoietic Stem Cell Transplantation2013

    • Author(s)
      Kato K
    • Organizer
      BMT Tandem Meetings
    • Place of Presentation
      Salt Lake City,USA
    • Year and Date
      2013-02-14
  • [Presentation] Statistical Analysis Methods in the Hisayama Study2013

    • Author(s)
      Yonemoto K
    • Organizer
      The 18th Hiroshima International Symposium "Additional factors in Hiroshima radiation effects due to atomic bomb-- Biophysical and biometrical challenges to assessing health hazard--"
    • Place of Presentation
      広島県
    • Year and Date
      2013-01-31
  • [Presentation] 再燃前立腺がんに対するテーラーメイドペプチドワクチン臨床試験参加患者末梢血単核球における遺伝子発現解析2012

    • Author(s)
      小松誠和
    • Organizer
      第71回日本癌学会
    • Place of Presentation
      札幌
    • Year and Date
      20120919-21
  • [Presentation] Associations Of Physical Activity And Fitness With Cognitive Status In Community-dwelling Older Adults2012

    • Author(s)
      Narazaki K
    • Organizer
      American College of Sports Medicine
    • Place of Presentation
      San Francisco
    • Year and Date
      2012-06-02
  • [Presentation] 食道扁平上皮癌における18F-FDG 集積とbiological parameter 関連性の検討2012

    • Author(s)
      廣瀬 靖光
    • Organizer
      JRC2012
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2012-04-14
  • [Presentation] 将来の胃癌発症予測のための血清ペプシノゲンのカットオフ値の検討 : 久山町研究2011

    • Author(s)
      志方健太郎
    • Organizer
      第21回日本疫学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2011-01-21
  • [Presentation] High serum bilirubin levels and diabetic retinopathy : the Hisayama Study2010

    • Author(s)
      Yasuda M
    • Organizer
      The third joint meeting of China-Korea-Japan ophthalmologists
    • Place of Presentation
      北京
    • Year and Date
      20100914-15
  • [Presentation] The impact of blood pressure on cardiovascular events in a general population : the Hisayama Study2010

    • Author(s)
      Fukuhara M
    • Organizer
      The 23rd scientific meeting of the international society of hypertention
    • Place of Presentation
      Vancouver Canada
    • Year and Date
      2010-09-28
  • [Presentation] 地域一般住民における血中レジスチンと慢性腎臓病(CKD)の関係 : 久山町研究2010

    • Author(s)
      川村良一
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山市
    • Year and Date
      2010-05-27

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Published: 2015-06-25  

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