2011 Fiscal Year Final Research Report
Physiological roles of exercise-and sarcopenia-induced interleukin-6 in skeletal muscle
| Project/Area Number |
22700659
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Sports science
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| Research Institution | Tokai University |
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Principal Investigator |
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| Research Collaborator |
MACHIDA Shuichi 東海大学, 体育学部, 准教授 (40421226)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 体力科学 |
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| Research Abstract |
We examined the effect of exercise-and sarcopenia-induced interleukin-6(IL-6) on the proliferative potential of satellite cells in primary cell culture. We demonstrated that IL-6 has an effect on proliferative potential of satellite cells in a dose-dependent manner, and IL-6 regulates proliferation and differentiation of satellite cell through induction of Cyclin D1 and SOCS3 by activation of JAK/STAT3 pathway.
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