Ror1-mediated signaling and its role in development and cancer

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790291
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Kobe University
• Principal Investigator: NISHITA Michiru 神戸大学, 大学院・医学研究科, 准教授 (30379359)
• Project Period (FY): 2010 – 2011
• Keywords: Ror受容体チロシンキナーゼ / Wnt / がん

Research Abstract

Mouse embryonic fibroblasts isolated from Ror1 ; Ror2 double knockout mice and human Burkitt's lymphoma cells were used to study their responses to Wnt5a. We found that inhibition of Wnt/.-catenin signaling by Wnt5a is mediated not only by Ror2 but also by Ror1. We also found that Ror1 is overexpressed in human triple-negative breast cancer cells and thereby activates signaling molecules, such as c-Src, Akt, Erk and Stat3, and cell proliferation.

Research Products

• [Journal Article] Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis (2012)
  • Author(s): Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., Nishita, M., Marumo, K., Martin, T. J., Minami, Y., and Takahashi, N.
  • Journal Title: Nat. Med Volume: 18 Pages: 405-412
  • Peer Reviewed
• [Journal Article] Ror-family receptor tyrosine kinases regulate maintenance of neural progenitor cells in the developing neocortex (2012)
  • Author(s): Endo, M., Doi, R., Nishita, M., and Minami, Y.
  • Journal Title: J. Cell Sci
  • Peer Reviewed
• [Journal Article] Dissection of Wnt5a-Ror2 Signaling Leading to Matrix Metalloproteinase(MMP-13) Expression (2012)
  • Author(s): Yamagata, K., Li, X., Ikegaki, S., Oneyama, C., Okada, M., Nishita, M., and Minami, Y.
  • Journal Title: J. Biol. Chem Volume: 287 Pages: 1588-1599
  • Peer Reviewed
• [Journal Article] Critical role of Wnt5a. Ror2 signaling in motility and invasiveness of carcinoma cells following Snail-mediated epithelial-mesenchymal transition (2011)
  • Author(s): Ren, D., * Minami, Y., and* Nishita, M.
  • Journal Title: Genes Cells Volume: 16 Pages: 304-315
  • Peer Reviewed
• [Journal Article] Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization (2010)
  • Author(s): Nishita, M., Itsukushima, S., Nomachi, A., Endo, M., Wang, Z., Inaba, D., Qiao, S., Takada, S., Kikuchi, A., and* Minami, Y.
  • Journal Title: Mol. Cell. Biol Volume: 30 Pages: 3610-3619
  • Peer Reviewed
• [Journal Article] Cell/tissue-tropic functions of Wnt5a signaling in normal and cancer cells (2010)
  • Author(s): Nishita, M., Enomoto, M., Yamagata, K., and Minami, Y.
  • Journal Title: Trends Cell Biol Volume: 20 Pages: 346-354
  • Peer Reviewed
• [Patent(Industrial Property Rights)] 疾患モデルとしての細胞種・組織特異的Ror2ノックアウトマウス (2011)
  • Inventor(s): 南康博、西田満、可児修一
  • Industrial Property Rights Holder: 神戸大学
  • Industrial Property Number: 特許、特願2011-071014
  • Filing Date: 2011-03-28