2012 Fiscal Year Final Research Report
The expression and role ofTGF‐β1 binding protein subtype on carcinogenesis
| Project/Area Number |
22790542
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | TGF-β1 / LTBP-1L / 発癌 |
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| Research Abstract |
Knockdown of LTBP-1L or LTBP-1S in cancer cell lines including stomach cancer, ovarian cancer, uterine cancer, colorectal cancer, had no remarkable change in cell shape, cell growth and cell invasion activity. Forced expression of LTBP-1L or LTBP-1S also showed no remarkable effect on cancer cell lines. On the other hand, there was correlation between LTBP-1 expression and cancer - stroma relationship of stomach cancer by immunohistochemical analysis in clinical samples (p < 0.01). Thus, it was suggested that LTBP-1 can be a candidate of the diagnostic marker and the target of medical treatment. However, further studies were required to determine the LTBP-1L and LTBP-1S function.
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Research Products
(10 results)
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[Journal Article] Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy2013
Author(s)
Kitano A, Shimasaki T, Chikano Y, Nakada M, Hirose M, Higashi T,Ishigaki Y, Endo Y, Takino T, Sato H, Sai Y, Miyamoto K, Motoo Y, Kawakami K, Minamoto T
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Journal Title
PLoS One
Volume: 8
Pages: e55289
DOI
Peer Reviewed
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[Journal Article] hylogenetic analysis of atmospheric halotolerant bacterial communities at high altitude in an Asian dust (KOSA) arrival region, Suzu City2010
Author(s)
T. Maki, S. Susuki, F. Kobayashi, M. Kakikawa, Y. Tobo, M. Yamada, T. Higashi, A. Matsuki, C. Hong, H. Hasegawa, Y. Iwasaka
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Journal Title
Science of the Total Environment
Volume: 408
Pages: 4556-4562
DOI
Peer Reviewed
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[Presentation] Health Effect of Kosa Aerosol.2012
Author(s)
Higashi T, Kambayashi Y, Fujimura M,Ohkura N, Yoshizaki T, Nakanishi S, Saijoh K, Hayakawa K, Kobayashi F, Michigami Y, Hitomi Y, Asakura H,Yamazaki M, Mitoma J,Horii M and Nakamura H.
Organizer
International Symposium on Aerosols in East Asia and their Impacts on Plants and Human Health
Place of Presentation
Tokyo University of Agriculture and Technology, Tokyo,Japan.
Year and Date
2012-11-24
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[Presentation] Pathological role for deregulated glycogen synthase kinase (GSK) 3b in pancreatic cancer proliferation and invasion2010
Author(s)
A Kitano, T Shimasaki, Y Chikano, M Nakada, T Higashi, Y Ishigaki, Y Endo, Y Sai , K Miyamoto, Y Motoo, KKawakami, T Minamoto
Organizer
69th Annual Meeting of the Japanease Cancer Association
Place of Presentation
Osaka International Convention Center, Osaka, Japan
Year and Date
2010-09-24
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