2013 Fiscal Year Final Research Report
The effects of mutated MMP2 on bone and joint
| Project/Area Number |
22791386
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010-04-01 – 2014-03-31
|
| Keywords | 骨溶解症 / 骨破壊 / MMP2 |
|---|
| Research Abstract |
Mutations in MMP2 gene results in unique skeletal phenotype called osteolysis, which is characterized by multiple joint distraction and severe osteoporosis. The pathology of joint damages in osteolysis mimics rheumatoid synovitis, however, the underlining molecular mechanism how inactivated mutation in MMP2 results in osteolysis is largely unknown. In this study, we tried to develop an animal model for osteolysis. We have made a conditional transgenic mouse carring an mutated MMP2 gene, which can be over-expressed under specific condition. This mouse would be useful for understanding the roles of MMP2 during the development of osteolysis.
|
