Studies on biological function of glycoconjugates using synthetic probes and in vivo imaging

2014 Fiscal Year Final Research Report

• Project/Area Number: 23241074
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Chemical biology
• Research Institution: Osaka University
• Principal Investigator: FUKASE Koichi 大阪大学, 理学(系)研究科(研究院), 教授 (80192722)
• Co-Investigator(Kenkyū-buntansha): TANAKA Katsunori 大阪大学, 大学院理学研究科, 助教 (00403098) ; MANABE Yoshiyuki 大阪大学, 大学院理学研究科, 助教 (00632093)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 自然免疫リガンド / リピドA / ペプチドグリカン / N-グリカン / イメージング

Outline of Final Research Achievements

We have developed novel synthetic methods for the effective synthesis of glycoconjugates and achieved the synthesis and biological assay of various types of glycans and glycoconjugates. Some immunomodulating glycoconjugates were revealed as a prospective candidate for an immune adjuvant. We also synthesize N-glycans which have core fucose and bisecting GlcNAc to investigate its function. In vivo imaging of various kinds of N-glycans clearly showed that the structure of N-glycans have influence on their dynamics.

Free Research Field

天然物有機化学