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2013 Fiscal Year Final Research Report

Development of ultrasound field viewer using novel technique without Schlieren opticls

Research Project

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Project/Area Number 23300182
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionHokkaido University

Principal Investigator

KUDO Nobuki  北海道大学, 情報科学研究科, 准教授 (30271638)

Co-Investigator(Kenkyū-buntansha) SHIMIZU Koichi  北海道大学, 大学院・情報科学研究科, 教授 (30125322)
NISHIDA Mutsumi  北海道大学, 大学病院, 臨床検査副技師長,超音波センター副部長 (90404722)
Research Collaborator MIZOJIRI Jun  溝尻光学工業所, 代表取締役
OBARA Koki  
SEKINE Daiki  
SUMIYOSHI Koki  北海道大学, 大学院・情報科学研究科, 修士課程学生
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords超音波音場 / 可視化 / シュリーレン法 / 超音波診断装置 / 超音波治療装置
Research Abstract

Ultrasound techniques have been playing important roles both in diagnosis and therapy. As a basic technology to support development of these applications, improvements are also required for evaluation techniques of ultrasound fields. In this study, an ultrasound field visualization system using image subtraction Schlieren technique was designed and fabricated with corroboration of an experienced manufacture. The developed system was used for visualization of ultrasound fields generated by clinically used diagnostic and therapeutic ultrasound equipment. Short-pulsed ultrasound fields for diagnostic applications and continuous-wave high-intensity focused ultrasound fields for therapeutic applications were successfully visualized, indicating practical usefulness of our technique as basic technology to support further progress of ultrasound applications in medicine.

  • Research Products

    (18 results)

All 2013 2012 2011

All Journal Article (9 results) (of which Peer Reviewed: 6 results) Presentation (9 results) (of which Invited: 4 results)

  • [Journal Article] Effects of cell culture scaffold stiffness on cell membrane damage induced by sonoporation2013

    • Author(s)
      Kudo N, Kinoshita Y
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: (in print)

    • DOI

      10.1007/s10396-014-0531-z

    • Peer Reviewed
  • [Journal Article] Ultrasound image-guided therapy enhances antitumor effect of cisplatin2013

    • Author(s)
      Sasaki N, Kudo N, Nakamura K, Lima SY, Murakami M, Kumara WRB, Tamura Y, Ohta H, Yamasaki M, and Takiguchi M
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: 41(1) Pages: 11-21

    • DOI

      10.1007/s10396-013-0475

    • Peer Reviewed
  • [Journal Article] Basic studies on sonoporation with size- and position-controlled microbubbles adjacent to cells2013

    • Author(s)
      Kudo N, Tanaka Y and Uchida K
    • Journal Title

      IEEE Ultrasonics Symposium Proceedings

      Pages: 53-56

    • Peer Reviewed
  • [Journal Article] Relation between cell membrane tension and repair of membrane damaged during sonoporation2013

    • Author(s)
      Tanaka Y, and Kudo N
    • Journal Title

      IEEE Ultrasonics Symposium Proceedings

      Pages: 1777-170

    • Peer Reviewed
  • [Journal Article] 画像差分シュリーレン装置の改良と超音波診断装置音場の可視化2013

    • Author(s)
      関根大輝, 工藤信樹, 清水孝一
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 113(103) Pages: 39-44

  • [Journal Article] A study on sonoporation of cells cultured on a soft collagen gel scaffold2012

    • Author(s)
      Kudo N, and Kinoshita Y
    • Journal Title

      AIP Conference Proceedings 2012

      Volume: 1503 Pages: 61-64

    • DOI

      10.1063/1.4769918

    • Peer Reviewed
  • [Journal Article] Activation of microbubbles by short-pulsed ultrasound enhances the cytotoxic effect of cisdiamminedichloroplatinum (II) in a canine thyroid adenocarcinoma cell line in vitro2012

    • Author(s)
      Sasaki N, Kudo N, Nakamura K, Lim SY, Murakami M, Kumara WRB, Tamura Y, Ohta H, Yamasaki M, and Takiguchi M
    • Journal Title

      Ultrasound in Medicine and Biology

      Volume: 38(1) Pages: 109-118

    • Peer Reviewed
  • [Journal Article] 画像差分型シュリーレン法を用いた超音波音場の可視化2012

    • Author(s)
      工藤信樹
    • Journal Title

      日本超音波医学会基礎技術研究会資料

      Volume: 2012(2) Pages: 49-52

  • [Journal Article] 画像差分シュリーレン法による治療用超音波音場の可視化~シャーレ内の定在波音場の可視化~2011

    • Author(s)
      小原浩貴, 工藤信樹, 清水孝一
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 111(88) Pages: 31-35

  • [Presentation] Experimental system for sonoporation with size- and location-controlled microbubbles2013

    • Author(s)
      Kudo N, Tanaka Y, and Uchida K
    • Organizer
      International Conference on Biomedical Ultrasound
    • Place of Presentation
      Taipei University (Taipei, Taiwan)
    • Year and Date
      20131022-23
    • Invited
  • [Presentation] Safety of ultrasound contrast agent2013

    • Author(s)
      Kudo N
    • Organizer
      5th Asian Conference on Ultrasound Contrast Imaging
    • Place of Presentation
      Veterans General Hospital (Taipei, Taiwan)
    • Year and Date
      20131019-20
    • Invited
  • [Presentation] Effects of water surface conditions on standing wave fields generated inside a small chamber2013

    • Author(s)
      Kudo N
    • Organizer
      Focused Ultrasound Therapy- Second European Symposium
    • Place of Presentation
      Roma Eventi - Fontana di Trevi (Rome, Itary)
    • Year and Date
      20131010-11
  • [Presentation] Cell damage and repair during sonoporation2013

    • Author(s)
      Kudo N
    • Organizer
      Artimino Ultrasound Conference 2013
    • Place of Presentation
      Windermere House, Lake Rosseau (0ntario, Canada)
    • Year and Date
      20130616-21
  • [Presentation] 画像差分型シュリーレン法による超音波音場可視化2013

    • Author(s)
      工藤信樹
    • Organizer
      第6回超音波とマイクロバブルの相互作用に関するシンポジウム
    • Place of Presentation
      滋賀医科大学看護第四講義室(滋賀県大津市)
    • Year and Date
      2013-12-20
    • Invited
  • [Presentation] 画像差分型シュリーレン法による超音波音場可視化の原理2013

    • Author(s)
      工藤信樹
    • Organizer
      日本超音波医学会平成25年度第3回光超音波画像研究会
    • Place of Presentation
      東北大学工学部(仙台市青葉区)
    • Year and Date
      2013-10-03
  • [Presentation] Visualization of therapeutic ultrasound fields in small chamber using image subtraction Schlieren technique2012

    • Author(s)
      Obara K, Kudo N, and Shimizu K
    • Organizer
      Symposium on Ultrasonic Electronics
    • Place of Presentation
      Chiba University (Inage-ku, Chiba)
    • Year and Date
      20121120-22
  • [Presentation] 画像差分型シュリーレン法を用いた超音波音場の可視化2012

    • Author(s)
      工藤信樹
    • Organizer
      日本超音波医学会基礎技術研究会
    • Place of Presentation
      北海道大学工学部(札幌市北区)
    • Year and Date
      2012-08-03
    • Invited
  • [Presentation] Visualization of ultrasound fields ins ide a smal l chamber used for sonoporation study2011

    • Author(s)
      Kudo N
    • Organizer
      13th World Congress of Ultrasound in Medicine and Biology
    • Place of Presentation
      Austria Center Vienna (Vienna, Austria)
    • Year and Date
      2011-08-26

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Published: 2015-06-25  

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