2013 Fiscal Year Final Research Report
Development of cancer therapy inducing histone acethylation at the specific region of cancer genome
| Project/Area Number |
23300344
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Carcinogenesis
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
NAGASE Hiroki 千葉県がんセンター(研究所), がん遺伝創薬研究室, 研究所長 (90322073)
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| Co-Investigator(Kenkyū-buntansha) |
渡部 隆義 (60526060)
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| Co-Investigator(Renkei-kenkyūsha) |
板東 俊和 (20345284)
杉山 弘 (50183843)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | ピロールイミダゾールポリアミド / ヒストンアセチル化 / ヒストン脱アセチル化酵素阻害剤 / がん |
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| Research Abstract |
Tumor suppressor genes have anti-tumor effect leading antiproliferative and antiapoptotic effects. Tumor also repress expression of tumor specific antigen to escape immunological reaction against cancer. We are generating drugs of DNA sequence-specific Pyrrole-Imidazole polyamide-SAHA conjugates which reexpress repressed tumor suppressor gene endogenously in cancers. SAHA is an HDACi and activate gene expression. PIP can deliver SAHA to the specific gene. This PIP-SAHA may be a promising chemicals to cure cancer patients, effective drug has not yet been developed though. However in the course of this study we have successfully collaborated with Kyoto University and developed the drug which has generated iPS cells in mice.
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[Journal Article] Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole-imidazole polyamide, which targets E-box2014
Author(s)
Taniguchi M, Nakai Y, Ozaki T, Koshikawa N, Kojima T, Kataba M, Oguni A, Matsuda H, Yoshida Y, Tokuhashi Y, Fukuda N, Ueno T, Soma T, Nagase H
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Journal Title
FEBS Open Bio
Volume: (in press)
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[Journal Article] DNA hypomethylation at the ZNF206-exon 5 CpG island associated with neuronal differentiation in mice and development of neuroblastoma in humans2012
Author(s)
Kawashima H, Sugito K, Yoshizawa S, Uekusa S, Furuya T, Ikeda T, Koshinaga T, Shinojima Y, Hasegawa R, Mishra R, Igarashi J, Kimura M, Wang X, Fujiwara K, Gosh S and Nagase H
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Journal Title
International Journal of Oncology
Volume: 40
Pages: 31-39
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[Journal Article] A specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development2012
Author(s)
Hashizume O, Shimizu A, Yokota M, Sugiyama A, Nakad K, Miyoshi H, Itami M, Ohira M, Nagase H, Takenaga K, and Hayashi J-I
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Journal Title
Proc Natl Acad Sci U S A Jun 26
Volume: 109(26)
Pages: 10528-33
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[Journal Article] Synthetic small molecules for epigenetic activation of pluripotent genes in mouse embryonic fibroblasts
Author(s)
Pandian GN, Shinohara K, Ohtsuki A, Nakano Y, Minoshima M, Bando T, Nagase H, Yamada Y, Watanabe A, Terada N, Sato S, Morinaga H and Sugiyama H
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Journal Title
ChemBioChem
Volume: 12(18)
Pages: 2822-2
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[Journal Article] Nr4a3, a possibile oncogenic factor for neuroblastoma associated with CpGi methylation within the third exon
Author(s)
Uekusa S, Kawashima H, Sugito K, Yoshizawa S, Shinojima Y, Igarashi J, Ghosh S, Wang X, Fjiwara K, Ikeda T, Koshinaga T, Soma M and Nagase H
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Journal Title
International Journal of Oncology
Volume: (in press)
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[Presentation] 変異型KRAS を標的とした塩基配列特異的アルキル化剤によるマウス移植ヒト大腸癌の増殖抑制2013
Author(s)
井上貴博, 平岡桐子, 養田裕行, 杉本博一, 篠原憲一, 渡部隆義, 越川信子, 板東俊和, 杉山弘, 尾崎俊文, 永瀬浩喜
Organizer
第36回日本分子生物学会年会
Place of Presentation
神戸
Year and Date
20131203-06
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[Presentation] 変異型KRAS を標的とした 配列特異的アルキル化剤による腫瘍細胞の増殖抑制2013
Author(s)
平岡桐子, 井上貴博, 養田裕行, 杉本博一, 篠原憲一, 渡部隆義, 越川信子, 板東俊和, 杉山弘, 尾崎俊文, 永瀬浩喜
Organizer
第36回日本分子生物学会年会
Place of Presentation
神戸
Year and Date
20131203-06
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[Presentation] DNA hypomethylation at the ZNF 206-exon 5 CpG island associatd with neuronal differentiation in mice and development of neuroblastoma in humans2013
Author(s)
Kawashima H, Sugito K, Yoshizawa S, Uekusa S, Furuya T, Ikeda T, Koshinaga T , Shinojima Y, Hasegawa R, Mishra R, Igarashi J, Kimura M, Wang X, Fujiwara K, Gosh S, Nagase H
Organizer
第55回日本小児血液・がん学会学術集会
Place of Presentation
福岡
Year and Date
20131129-1201
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[Presentation] 腎芽腫細胞株(G401)におけるKCNQ10T1遺伝子を標的としたPYRROLE‐IMIDAZOLE POL YAMIDE(PIP)の抗腫瘍効果の検討2013
Author(s)
吉澤信輔, 杉藤公信, 星玲奈, 渡邉揚介,植草省太, 川島弘之, 大橋研介, 池田太郎,越永従道, 吉澤信輔, 星玲奈, 渡邉揚介, 藤原恭子, 永瀬浩喜
Organizer
第55回日本小児血液・がん学会学術集会・第11回日本小児がん看護学会・第18回がんの子供を守る会公開シンポジウム
Place of Presentation
福岡
Year and Date
20131129-1201
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