2013 Fiscal Year Final Research Report
Creation of Novel Biofunctional Molecules for Target-Selective Photodegradation of Proteins and Carbohydrates
| Project/Area Number |
23310153
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 生体機能分子 / 光分解 / タンパク / 糖鎖 / 有機合成 / 細胞 |
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| Research Abstract |
Novel light-activatable and biofunction-control molecules, that target-selectively photodegrade certain disease-related proteins and oligosaccharides, were designed and synthesized. Furthermore, it was found the molecules thus developed work not only in test tube but also in disease-related cells. From these studies, a new and innovative approach for the design of molecular-targeted bio-probes and medicines has been established.
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Research Products
(50 results)
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[Journal Article] Molecular design, chemical synthesis, and biological evaluation of agents that selectively photo-degrade the transcription factor estrogen receptor-2011
Author(s)
K. Tsumura, A. Suzuki, T. Tsuzuki, S. Tanimoto, H. Kaneko, S. Matsumura, M. Imoto, K. Umezawa, D. Takahashi, K. Toshima
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Journal Title
Organic & Biomolecular Chemistry
Volume: 9
Pages: 6357-6366
DOI
Peer Reviewed
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[Remarks] 2012年4月4日掲載日刊工業新聞朝刊「慶大 インフル抑制分子を開発, 増殖因子に結合, 光で分解, 耐性ウィルスに効果」(新聞掲載)
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[Remarks] 2011年4月13日掲載日刊工業新聞朝刊「アルツハイマーの原因物質光で狙い撃ち, 慶大, フラーレンで複合分子」(新聞掲載)
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