2013 Fiscal Year Final Research Report
Development of a new type of cancer vaccine for dog malignancy
| Project/Area Number |
23380186
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SHIMIZU Kanako 独立行政法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (20391980)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUNO Takuya 山口大学, 共同獣医学部, 教授 (90398826)
FUJII Shin-ichiro 独立行政法人理化学研究所, 統合生命医科学研究センター, チームリーダー (10392094)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 癌ワクチン / 自然免疫 / 獲得免疫 / NKT細胞 |
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| Research Abstract |
To make a strategy of new type of cancer vaccine for cancer-bearing dogs, we have launched the study of canine-type adjuvant vector cells, which may link between innate and adaptive immunity. In this study, we initially have chosen the canine vector cells and determining the optimal conditions for establishing the cells. Then, when we administered it through intravenous route, we detected the immune response in immunized dogs. These results would demonstrate the important and fundamental information for applying this strategy for canine immunotherapy in future.
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Research Products
(23 results)
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[Journal Article] Vaccination with antigen-transfected, NKT cell ligand-loaded, human cells elicits robust in situ immune responses by dendritic cells2013
Author(s)
Shimizu K, Mizuno T, Shinga J, Asakura M, Kakimi K, Ishii Y, Masuda K, Maeda T, Sugahara H, Sato Y, Matsushita H, Nishida K, Hanada KI, Dörrie J, Schaft N, Bickham K, Koike H, Ando T, Nagai R, Fujii S
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Journal Title
Cancer Res
Volume: 73
Pages: 62-73
DOI
Peer Reviewed
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[Journal Article] Accumulation of activated invariant natural killer T cells in the tumor microenvironment after α-galactosylceramide-pulsed antigen presenting cells2012
Author(s)
Nagato K, Motohashi S, Ishibashi F, Okita K, Yamasaki K, Moriya Y, Hoshino H, Yoshida S, Hanaoka H, Fujii S, Taniguchi M, Yoshino I, Nakayama T
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Journal Title
J Clin Immunol
Volume: 32
Pages: 1071-81
DOI
Peer Reviewed
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