2015 Fiscal Year Final Research Report

Early prevention strategy on lifestyle-related diseases regarding DOHaD based on self-measured home blood pressure

Research Project

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Project/Area Number	23390171
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Public health/Health science
Research Institution	Teikyo University (2013, 2015) Tohoku University (2011-2012, 2014)
Principal Investigator	Asayama Kei 帝京大学, 医学部, 講師 (80431518)
Co-Investigator(Kenkyū-buntansha)	KIKUYA Masahiro 東北大学, 東北メディカル・メガバンク機構, 准教授 (80361111) TATSUTA Nozomi 東北大学, 医学系研究科, 助教 (40547709)
Co-Investigator(Renkei-kenkyūsha)	IMAI Yutaka 東北大学, 薬学研究科, 教授 (40133946) OHKUBO Takayoshi 帝京大学, 医学部, 教授 (60344652) SATOH Hiroshi 東北大学, 医学系研究科, 名誉教授 (40125571) NAKAI Kunihiko 東北大学, 医学系研究科, 教授 (00291336)
Research Collaborator	Staessen Jan A. Thijs Lutgarde 保坂実樹佐藤倫広
Project Period (FY)	2011-04-01 – 2016-03-31
Keywords	家庭血圧 / DOHaD / 母乳栄養 / 母子保健 / 妊娠高血圧症候群 / 自由行動下血圧 / メタ解析
Outline of Final Research Achievements	The Tohoku Study of Child Development (TSCD) is a prospective birth cohort consisted of two areas in Japan. We measured home blood pressure of the mothers and of their 7-year-old children who participated in the TSCD for 2 weeks. We found that (1) breastfeeding has a protective effect against elevated blood pressure even in young children, and subtle, but important, differences were precisely detected by self-measurements performed at home, and (2) maternal pregnancy-induced hypertension (PIH) did not affect home blood pressure in offspring, but strongly affected maternal home blood pressure even 7 years after giving birth. From the longitudinal Ohasama cohort study, impacts of partial white-coat hypertension as well as partial masked hypertension for stroke risk were comparable to those of complete masked hypertension or sustained hypertension. Based on these 2 studies, we have unveiled further usefulness of self-measured home blood pressure.
Free Research Field	高血圧の疫学