2013 Fiscal Year Final Research Report
Construction of predictive algorithm for therapeutic effect and exploration of molecular targets in esophageal cancer by the next-generation integrated genome analysis
| Project/Area Number |
23390325
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
IMOTO Issei (橘 逸勢) 徳島大学, ヘルスバイオサイエンス研究部, 教授 (30258610)
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| Co-Investigator(Kenkyū-buntansha) |
TANGOKU Akira 徳島大学, 大学院・へルスバイオサイエンス研究部, 教授 (10197593)
YANAGAWA Hiroaki 徳島大学, 病院, 准教授 (50263827)
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| Co-Investigator(Renkei-kenkyūsha) |
TAJIMA Atsushi 徳島大学, 大学院・へルスバイオサイエンス研究部, 准教授 (10396864)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 食道癌 / ゲノム / エピゲノム / 遺伝子 / トランスレーショナルリサーチ / 次世代シーケンサー |
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| Research Abstract |
In order to make personalized medicine for esophageal squamous cell carcinoma (ESCC) , omics data were obtained from tumor samples with detailed clinical data in patients with ESCC treated by sufficiently systematized protocols through next generation sequencing- and microarray-based methods, and integrated. Through this approach, we constructed algorisms to perform the estimation of malignancy and prognosis of ESCC using molecular markers. In addition we identified novel candidate genes for a diagnostic, prognostic, prophylactic and/or therapeutic target in ESCC as well as other cancers, indicating our approach to be useful and widely applicable for various types of cancers.
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[Journal Article] The expression and clinical significance of connective tissue growth factor in advanced head and neck squamous cell cancer2014
Author(s)
Kikuchi R, Kikuchi Y, Tsuda H, Maekawa H, Kozaki KI, Imoto I, Tamai S, Shiotani A, Iwaya K, Sakamoto M, Sekiya T, Matsubara O
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in human gastric cancer2014
Author(s)
Hosoda F, Arai Y, Okada N, Hiroko Shimizu H, Miyamoto M, Kitagawa N, Katai H, T aniguchi H, Y anagihara K, Imoto I, Inazawa J, Ohki M, Shibata T
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Journal Title
DOI
Peer Reviewed
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[Journal Article] NF-κB inducing kinase, a central signaling 1 component of the non-canonical pathway of NF-κB, contributes to ovarian cancer progression2014
Author(s)
Uno M, Saitoh Y, Mochida K, Tsuruyama E, Kiyono T, Imoto I, Inazawa J, Yuasa Y, Kubota T, Yamaoka S
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Journal Title
PLoS One
Volume: 9(2)
Pages: e88347
DOI
Peer Reviewed
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[Journal Article] DNA methylation signatures of peripheral leukocytes in schizophrenia2013
Author(s)
Kinoshita M, Numata S, Tajima A, Shimodera S, Ono S, Imamura A, Iga JI, Watanabe S, Kikuchi K, Kubo H, Nakataki M, Sumitani S, Imoto I, Okazaki Y, Ohmori T
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Journal Title
Neuromolecular Med
Volume: 15(1)
Pages: 95-101
DOI
Peer Reviewed
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[Journal Article] The incidence of hypoplasia of the corpus callosum in patients with dup (X)(q28) involving MECP2 is associated with the location of distal breakpoints2012
Author(s)
Honda S, Hayashi S, Nakane T, Imoto I, Kurosawa K, Mizuno S, Okamoto N, Kato M, Yoshihashi H, Kubota T, Nakagawa E, Goto YI, Inazawa J
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Journal Title
Am J Med Genet A
Volume: 158A(6)
Pages: 1292-1303
DOI
Peer Reviewed
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[Journal Article] Deletion at chromosome 10p11.23-p12.1 defines characteristic phenotypes with marked midface retrusion2012
Author(s)
Okamoto N, Hayashi S, Masui A, Kosaki R, Oguri I, Hasegawa T, Imoto I, Makita Y, Hata A, Moriyama K, Inazawa J
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Journal Title
J Hum Genet
Volume: 57(3)
Pages: 191-196
DOI
Peer Reviewed
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[Journal Article] SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing2011
Author(s)
Matsui T, Miyamoto K, Kubo A, Kawasaki H, Ebihara T, Hata K, Tanahashi S, Ichinose S, Imoto I, Inazawa J, Kudoh J, Amagai M
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Journal Title
EMBO Mol Med
Volume: 3(6)
Pages: 320-333
DOI
Peer Reviewed
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[Journal Article] Genome-wide DNA methylation profiles in renal tumors of various histological subtypes and non-tumorous renal tissues2011
Author(s)
Arai E, Wakai-Ushijima S, Fujimoto H, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y
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Journal Title
Pathobiology
Volume: 78(1)
Pages: 1-9
DOI
Peer Reviewed
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