Encapsulated neural stem cell transplantation for Parkinson's Disease

2013 Fiscal Year Final Research Report

• Project/Area Number: 23390349
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Okayama University
• Principal Investigator: DATE Isao 岡山大学, 医歯(薬)学総合研究科, 教授 (70236785)
• Co-Investigator(Kenkyū-buntansha): AGARI Takashi 岡山大学, 岡山大学病院, 助教 (60423290) ; KAMEDA Masahiro 岡山大学, 医歯薬学総合研究科, 助教 (50586427) ; ONO Shigeki 川崎医科大学, 医学部, 教授 (40335625)
• Co-Investigator(Renkei-kenkyūsha): SUGIU Kenji 岡山大学, 岡山大学病院, 准教授 (40325105) ; TOKUNAGA Koji 岡山大学, 医歯薬学総合研究科, 准教授 (40294467) ; ICHIKAWA Tomotsugu 岡山大学, 医歯薬学総合研究科, 講師 (10362964) ; KUROZUMI Kazuhiko 岡山大学, 岡山大学病院, 講師 (20509608) ; HISHIKAWA Tomohito 岡山大学, 岡山大学病院, 助教 (60509610)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: 実験脳外科学 / カプセル化神経幹細胞移植

Research Abstract

It is necessary to enhance the survival of encapsulated cells in order to enhance secretion of trophic factor from encapsulated cells. We examined whether GDNF pre-treatment could enhance the survival of neural stem cells. Under the ischemic-like injury by oxygen-glucose deprivation, the number of apoptotic cells was significantly decreased by GDNF pre-treatment. Moreover, the number of survival cells after transplantation for Parkinson's model of rat was significantly increased by GDNF pre-treatment. Based on these results, GDNF pre-treatment enhances the survival of neural stem cells by suppression of apoptosis.

Research Products

• [Journal Article] Mannitol enhances therapeutic effects of intra-arterial transplantation of mesenchymal stem cells into the brain after traumatic brain injury (2013)
  • Author(s): Okuma Y, Wang F, Toyoshima A, Kameda M, Hishikawa T, Tokunaga K, Sugiu K, Liu K, Haruma J, Nishibori M, Yasuhara T, Date I
  • Journal Title: Neurosci Lett Volume: 554 Pages: 156-61
  • DOI: 10.1016/j.neulet.2013.08.058
  • Peer Reviewed
• [Journal Article] Neuroprotective effects of liraglutide for stroke model of rats (2013)
  • Author(s): Sato K, Kameda M, Yasuhara T, Agari T, Baba T, Wang F, Shinko A, Wakamori T, Toyoshima A, Takeuchi H, Sasaki T, Sasada S, Kondo A, Borlongan CV, Matsumae M, Date I
  • Journal Title: Int J Mol Sci Volume: 14 Pages: 21513-24
  • DOI: 10.3390/ijms141121513
  • Peer Reviewed
• [Journal Article] Regenerative medicine for epilepsy : from basic research to clinical application (2013)
  • Author(s): Yasuhara T, Agari T, Kameda M, Kondo A, Kuramoto S, Jing M, Sasaki T, Toyoshima A, Sasada S, Sato K, Shinko A, Wakamori T, Okuma Y, Miyoshi Y, Tajiri N, Borlongan CV, Date I
  • Journal Title: Int J Mol Sci Volume: 14 Pages: 23390-401
  • DOI: 10.3390/ijms141223390
  • Peer Reviewed
• [Journal Article] パーキンソン病の外科治療 (2013)
  • Author(s): 上利 崇, 伊達 勲
  • Journal Title: Mebio Volume: 30(11) Pages: 58-64
  • Peer Reviewed
• [Journal Article] The neuroprotective and neurorescue effects of carbamylated erythropoietin Fc fusion protein (CEPO-Fc) in a rat model of Parkinson's disease (2013)
  • Author(s): Tayra JT, Kameda M, Yasuhara T, Agari T, Kadota T, Wang F, Kikuchi Y, Liang H, Shinko A, Wakamori T, Vcelar B, Weik R, Date I
  • Journal Title: Brain Research Volume: 1502 Pages: 55-70
  • DOI: 10.1016/j.brainres.2013.01.042
  • Peer Reviewed
• [Journal Article] Intravenous grafts of amniotic fluid-derived stem cells induce endogenous cell proliferation and attenuate behavioral deficits in ischemic stroke rats (2012)
  • Author(s): Tajiri N, Acosta S, Glover LE, Bickford PC, Jacotte Simancas A, Yasuhara T, Date I, Solomita MA, Antonucci I, Stuppia L, Kaneko Y
  • Journal Title: Borlongan CV PLoS One Volume: 7 Pages: e43779
  • DOI: 10.1371/journal.pone.0043779
  • Peer Reviewed
• [Journal Article] The therapeutic potential of human umbilical cord blood transplantation for neonatal hypoxic-ischemic brain injury and ischemic stroke (2012)
  • Author(s): Wang F, Maeda N, Yasuhara T, Kameda M, Tsuru E, Yamashita Y, Shen Y, Tsuda M, Date I, Sagara Y
  • Journal Title: Acta Medica Okayama Volume: 66(6) Pages: 429-434
  • Peer Reviewed
• [Journal Article] Anti-high mobility group box-1 antibody therapy for traumatic brain injury (2012)
  • Author(s): Okuma Y, Liu K, Wake H, Zhang J, Maruo T, Date I, Yoshino T, Ohtsuka A, Otani N, Tomura S, Shima K, Yamamoto Y, Yamamoto H, Takahashi H K, Mori S, Nishibori M
  • Journal Title: Annals of Neurology Volume: 72 Pages: 373-384
  • DOI: 10.1002/ana.23602
  • Peer Reviewed
• [Journal Article] 脊髄刺激療法 (2012)
  • Author(s): 上利 崇, 伊達 勲
  • Journal Title: 神経治療学 Volume: 29(3) Pages: 337-340
  • Peer Reviewed
• [Journal Article] パーキンソン病モデルラットに対する間葉系幹細胞移植の治療効果 (2012)
  • Author(s): 王 飛霏, 安原隆雄, 亀田雅博, 伊達 勲
  • Journal Title: 岡山医学会雑誌 Volume: 124 Pages: 111-114
  • Peer Reviewed
• [Journal Article] GDNF-pretreatment enhances the survival of neural stem cells following transplantation in a rat model of Parkinson's disease (2011)
  • Author(s): Wang F, Kameda M, Yasuhara T, Tajiri N, Kikuchi Y, Liang HB, Tayra JT, Shinko A, Wakamori T, Agari T, Date I
  • Journal Title: Neurosci Res Volume: 71(1) Pages: 92-8
  • DOI: 10.1016/j.neures.2011.05.019
  • Peer Reviewed
• [Journal Article] Striatal stimulation nurtures endogenous neurogenesis and angiogenesis in chronic-phase ischemic stroke rats (2011)
  • Author(s): Morimoto T, Yasuhara T, Kameda M, Baba T, Kuramoto S, Kondo A, Takahashi K, Tajiri N, Wang F, Meng J, Ji YW, Kadota T, Maruo T, Kinugasa K, Miyoshi Y, Shingo T, Borlongan CV, Date I
  • Journal Title: Cell Transplant Volume: 20(7) Pages: 1049-64
  • DOI: 10.3727/096368910X544915
  • Peer Reviewed
• [Journal Article] Mesenchymal stem cell transplantation therapy for Parkinson's disease and cerebral ischemia (2011)
  • Author(s): Wang F, Yasuhara T, Kameda M, Date I
  • Journal Title: Current Trends in Neurology Volume: 5 Pages: 13-16
  • Peer Reviewed
• [Journal Article] Urinary 8-OHdG elevations in a partial lesion rat model of Parkinson's disease correlate with behavioral symptoms and nigrostriatal dopaminergic depletion (2011)
  • Author(s): Kikuchi Y, Yasuhara T, Agari T, Kondo A, Kuramoto S, Kameda M, Kadota T, Baba T, Tajiri N, Wang F, Tayra JT, Liang H, Miyoshi Y, Borlongan CV
  • Journal Title: Date I Journal of Cellular Physiology Volume: 226(5) Pages: 1390-1398
  • DOI: 10.1002/jcp.22467
  • Peer Reviewed
• [Journal Article] BDNF-secreting capsule exerts neuroprotective effects on epilepsy model of rats (2011)
  • Author(s): Kuramoto S, Yasuhara T, Agari T, Kondo A, Jing M, Kikuchi Y, Shinko A, Wakamori T, Kameda M, Wang F, Kin K, Edahiro S, Miyoshi Y, Date I
  • Journal Title: Brain Research Volume: 1368 Pages: 281-289
  • DOI: 10.1016/j.brainres.2010.10.054
  • Peer Reviewed
• [Journal Article] 脳梗塞の再生療法 (2011)
  • Author(s): 伊達 勲
  • Journal Title: 夢 Volume: 21 7 Pages: 96-97
  • Peer Reviewed
• [Journal Article] 脳神経外科医教育における基礎研究の意義 (2011)
  • Author(s): 伊達 勲
  • Journal Title: 脳神経外科ジャーナル Volume: 20(2) Pages: 115-121
  • Peer Reviewed
• [Presentation] 経動脈的骨髄幹細胞移植の移植時期による治療効果の違い-一過性脳虚血モデルラットを用いた検討 (2014)
  • Author(s): 豊嶋敦彦, 安原隆雄, 亀田雅博, 竹内勇人, 佐藤顕一郎, 佐々木達也, 佐々田晋, 新光阿以子, 上利 崇, 伊達勲
  • Organizer: 第39回日本脳卒中学会総会 : STROKE 2014
  • Place of Presentation: 大阪
  • Year and Date: 2014-03-14
• [Presentation] ラット一過性中大脳動脈閉塞モデルに対するGLP-1 受容体作動薬リラグルチド投与の効果 (2014)
  • Author(s): 佐藤顕一郎, 亀田雅博, 安原隆雄, 上利 崇, 王 飛霏, Judith Tayra , 新光阿以子, 若森孝彰, 豊嶋敦彦, 竹内勇人, 馬場胤典, 松前光紀, 伊達 勲
  • Organizer: 第13回日本再生医療学会総会
  • Place of Presentation: 京都
  • Year and Date: 2014-03-04
• [Presentation] パーキンソン病の外科治療最前線-脳深部・脊髄刺激療法 (2014)
  • Author(s): 伊達 勲
  • Organizer: 第7回京都神経内科学アカデミー
  • Place of Presentation: 京都
  • Year and Date: 2014-02-08
• [Presentation] パーキンソン病モデルラットに対する脊髄刺激による神経保護効果-神経栄養因子・成長因子の検討-新光阿以子 (2014)
  • Author(s): 上利 崇, 安原隆雄, 亀田雅博, 近藤聡彦, 佐々木達也, 佐々田晋, 佐藤顕一郎, 竹内勇人, 若森孝彰, 伊達 勲
  • Organizer: 第53回日本定位・機能神経外科学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-02-08
• [Presentation] Cognitive functions in patients with Parkinson's disease before deep brain stimulation of the-subthalamic nucleus (2014)
  • Author(s): Wakamori T, Agari T, Kondo A, Shinko A, Sasada S, Sasaki T, Kameda M, Yasuhara T, Date I
  • Organizer: The 9th Scientific Meeting for the Asian Australasian Society of Stereotactic and Functional Neurosurgery (AASSFN 2014)
  • Place of Presentation: Shanghai, China
  • Year and Date: 2014-01-11
• [Presentation] The long-term results of subthalamic nucleus stimulation for Parkinson's disease (2014)
  • Author(s): Sasaki T, Agari T, Shinko A, Sasada S, Wakamori T, Kondo A, Kameda M, Yasuhara T, Date I
  • Organizer: The 9th Scientific Meeting for the Asian Australasian Society of Stereotactic and Functional Neurosurgery (AASSFN 2014)
  • Place of Presentation: Shanghai, China
  • Year and Date: 2014-01-11
• [Presentation] Improvement of surgical technique and outcome in re-operation for subthalamic nucleus deep brain stimulation (STN-DBS) (2014)
  • Author(s): Agari T, Kondo A, Shinko A, Sasada S, Sasaki T, Wakamori T, Kameda M, Yasuhara T, Date I
  • Organizer: The 9th Scientific Meeting for the Asian Australasian Society of Stereotactic and Functional Neurosurgery (AASSFN 2014)
  • Place of Presentation: Shanghai, China
  • Year and Date: 2014-01-11
• [Presentation] 脳深部刺激療法(DBS)治療を受けたパーキンソン病患者とパーキンソン症状を合併したdefinite iNPH(特発性正常圧水頭症)患者の画像比較 (2013)
  • Author(s): 亀田雅博, 伊達 勲
  • Organizer: 平成25年度厚生労働科学研究費補助金難治性疾患克服研究事業「特発性正常圧水頭症の病因・病態と診断・治療に関する研究」班班会議
  • Place of Presentation: 東京
  • Year and Date: 2013-11-22
• [Presentation] ソン病患者における幻覚と認知機能の関連 (2013)
  • Author(s): 若森孝彰, 上利 崇, 近藤聡彦, 新光阿以子, 佐々田晋, 佐々木達也, 亀田雅博, 安原隆雄, 伊達 勲
  • Organizer: 第7回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 東京
  • Year and Date: 2013-10-11
• [Presentation] パーキンソン病に対する最新外科治療-脳深部・脊髄刺激療法 (2013)
  • Author(s): 伊達 勲
  • Organizer: 第210回美作神経疾患研究会学術講演会
  • Place of Presentation: 津山
  • Year and Date: 2013-08-02
• [Presentation] 治療抵抗性の腰・下肢痛を合併したパーキンソン病患者に対するSCS の短・中期の効果 (2013)
  • Author(s): 上利崇, 安原隆雄, 近藤聡彦, 新光阿以子, 佐々田晋, 佐々木達也, 新治有径, 若森孝彰, 伊達 勲
  • Organizer: 第27回日本ニューロモデュレーション学会
  • Place of Presentation: 東京
  • Year and Date: 2013-05-18
• [Presentation] 進行期パーキンソン病における認知機能低下と脳血流評価 (2013)
  • Author(s): 若森孝彰, 上利 崇, 近藤聡彦, 新光阿以子, 佐々田晋, 佐々木達也, 亀田雅博, 安原隆雄, 伊達 勲
  • Organizer: 第20回カテコールアミンと神経疾患研究会
  • Place of Presentation: 東京
  • Year and Date: 2013-04-27
• [Presentation] 電気刺激を用いた再生医療-神経新生をめざして (2012)
  • Author(s): 亀田雅博, 安原隆雄, 馬場義美, 森本尊雅, 松前光紀, 伊達 勲
  • Organizer: 日本脳神経外科学会第71回学術総会
  • Place of Presentation: 大阪
  • Year and Date: 20121017-19
• [Presentation] Anti-high mobility group box-1 antibody therapy for traumatic brain injury (2012)
  • Author(s): Okuma Y, Liu K, Wake H , Maruo T, Teshigawara K , Tomura S, Otani N , Shima K , Yamamoto Y, Yamamoto H, Takahashi H , Mori S , Date I , Nishibori M
  • Organizer: Society for Neuroscience 42nd Annual Meeting
  • Place of Presentation: New Orleans, U.S.A
  • Year and Date: 20121013-17
• [Presentation] パーキンソン病モデルラットに対するCEPO の融合タンパク質への神経保護効果 平 ジュディッチ (2012)
  • Author(s): 亀田雅博, 安原隆雄, 上利 崇, 門田知倫, 王 飛霏, 菊池陽一郎, 梁 晗柏, 新光阿以子, 若森孝彰, 佐藤顕一郎, 伊達 勲
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 20120918-21
• [Presentation] 電気刺激療法と再生-神経新生をめざして (2012)
  • Author(s): 亀田雅博, 安原隆雄, 馬場胤典, 森本尊雅, Taylro CJ , Abraham WC , Bartlett PF , Borlongan CV , 松前光紀, 伊達 勲
  • Organizer: 第11回日本再生医療学会総会
  • Place of Presentation: 横浜
  • Year and Date: 20120613-14
• [Presentation] The potential of carbamylated erythropoietin fusion protein on parkinson's disease model of rats (2012)
  • Author(s): タイラ ジュディッチ, 亀田雅博, 安原隆雄, 王 飛霏, 菊池陽一郎, 梁 晗柏, 新光阿以子, 若森孝彰, 上利崇, 伊達 勲
  • Organizer: 第19回カテコールアミンと神経疾患研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-12
• [Presentation] 長期増強は潜在的神経前駆細胞の活性化をもたらす (2011)
  • Author(s): 亀田雅博, Tara Walker, 伊達 勲, Perry Bartlett
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] 6-OHDA 投与ラットにおける移植前神経幹細胞に対するGDNF 前投与の神経保護効果 (2011)
  • Author(s): 王 飛霏, 道上宏之, 亀田雅博, 西木禎一, 大守伊織, 伊達 勲, 松井秀樹
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-15
• [Presentation] 移植時低酸素・虚血負荷に対するGDNF 前投与による神経幹細胞への保護効果 (2011)
  • Author(s): 王 飛霏, 亀田雅博, 安原隆雄, 菊池陽一郎, 平ジュディッチ トーマス, 梁 晗柏, 新光阿以子, 若森孝彰, 三好康之, 伊達 勲
  • Organizer: 第36回日本脳卒中学会総会
  • Place of Presentation: STROKE 2011:京都
  • Year and Date: 2011-07-31
• [Presentation] Potential of carbamylated erythropoietin fusion protein on parkinson's disease model of rat Judith Thomas Tayra (2011)
  • Author(s): 亀田雅博, 安原隆雄, 三好康之, 伊達 勲
  • Organizer: 神経組織の成長・再生・移植研究会第26回学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-25
• [Presentation] パーキンソン病に対する外科治療-脳深部刺激療法と再生療法 (2011)
  • Author(s): 伊達 勲
  • Organizer: 北海道大学細胞療法研究会
  • Place of Presentation: 札幌
  • Year and Date: 2011-04-26
• [Book] Advances in Regenerative Medicine (2011)
  • Author(s): Kameda M
  • Total Pages: 404
  • Publisher: In Tech