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2013 Fiscal Year Final Research Report

Study for insulin resistance in obstetric and gynecologic diseases

Research Project

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Project/Area Number 23390390
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionOkayama University

Principal Investigator

HIRAMATSU Yuji  岡山大学, 医歯(薬)学総合研究科, 教授 (80218817)

Co-Investigator(Kenkyū-buntansha) MASUYAMA Hisashi  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (30314678)
KAMADA Yasuhiko  岡山大学, 病院, 講師 (70346427)
NAKAMURA Keiichiro  岡山大学, 病院, 講師 (90359886)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywordsインスリン抵抗性 / 妊娠 / 妊娠糖尿病 / 妊娠高血圧症候群 / 多嚢胞性卵巣症候群 / 子宮体癌 / 肥満
Research Abstract

Insulin resistance (IR) increases under some conditions such as pregnancy, polycystic ovary syndrome (PCOS) and endometrial cancer. In this study we aimed to reveal the roll of IR in such conditions. IR is closely related with gestational diabetes mellitus (GDM), especially in women with obesity. IR was also closely related with the metabolism of adipocytokine. Thus, exposure to a high-fat diet in utero might cause a metabolic syndrome-like phenomenon through epigenetic modifications of adipocytokine, adiponectin, and leptin gene expression. IR is increased in PCOS patients and the occurrence of GDM and preeclampsia increased in these patients. Type I endometrial cancer has a statistically significant increase in obesity-related biological parameters than type II endometrial cancer. Subcutaneous fat accumulation in adipose tissue is a strong risk factor for developing type I endometrial cancer and also close relationship with IR.

  • Research Products

    (53 results)

All 2013 2012 2011 Other

All Journal Article (39 results) (of which Peer Reviewed: 28 results) Presentation (5 results) Book (9 results)

  • [Journal Article] 妊娠糖尿病の診断と産後のフォローアップ2013

    • Author(s)
      平松祐司
    • Journal Title

      日産婦誌

      Volume: 65(3) Pages: 1125-1132

    • Peer Reviewed
  • [Journal Article] 糖尿病合併妊娠, 妊娠糖尿病ー定義の変更2013

    • Author(s)
      平松祐司
    • Journal Title

      日産婦誌

      Volume: 65(1) Pages: N3-N9

    • Peer Reviewed
  • [Journal Article] 妊娠糖尿病の頻度2013

    • Author(s)
      平松祐司
    • Journal Title

      月刊 糖尿病

      Volume: 5(6) Pages: 14-17

  • [Journal Article] 糖尿病と胎盤2013

    • Author(s)
      増山 寿, 舛本明生, 洲脇尚子, 平松祐司
    • Journal Title

      産婦人科の実際

      Volume: 62(8) Pages: 1073-1078

  • [Journal Article] 当院で治療した子宮体癌患者319症例の疫学的 調 査2013

    • Author(s)
      春間朋子, 中村圭一郎, 福島千加子, 楠本知行, 関 典子, 柳井広之, 平松祐司
    • Journal Title

      日本婦人科腫瘍学会雑誌

      Volume: 31(4) Pages: 1037-1042

    • Peer Reviewed
  • [Journal Article] Treatment with a constitutive androstane receptor ligand ameliorates the signs of preeclampsia in high-fat diet-induced obese pregnant mice2012

    • Author(s)
      Masuyama H, Hiramatsu Y
    • Journal Title

      Molecular and Cellular Endocrinology

      Volume: 348(1) Pages: 120-127

    • DOI

      10.1152/ajpendo.00167.2012

    • Peer Reviewed
  • [Journal Article] Determination of reference intervals of glycated albumin and hemoglobin A1c in healthy pregnant Japanese women and analysis of their time courses and influencing factors during pregnancy2012

    • Author(s)
      Hiramatsu Y, Shimizu I, Omori Y, Nakabayashi M
    • Journal Title

      Endocrine J

      Volume: 59 Pages: 145-151

    • URL

      https://www.jstage.jst.go.jp/article/endocrj/59/2/59_K10E-410/_pdf

    • Peer Reviewed
  • [Journal Article] Measurement of the minimum apparent diffusion coefficient (ADCmin) of the primary tumor and CA125 are predictive of disease recurrence for patients with endometrial cancer2012

    • Author(s)
      Nakamura K, Imafuku N, Nishida T, Niwa I, Joja I, Hongo A, Kodama J, Hiramatsu Y
    • Journal Title

      Gynecol Oncol

      Volume: 124(2) Pages: 335-339

    • DOI

      10.1016/j.ygyno.2011.10.014

    • Peer Reviewed
  • [Journal Article] Effects of a High-Fat Diet Exposure in Utero on the Metabolic Syndrome-Like Phenomenon in Mouse Offspring through Epigenetic Changes in Adipocytokine Gene Expression2012

    • Author(s)
      Masuyama H, Hiramatsu Y
    • Journal Title

      Endocrinology

      Volume: 153(6) Pages: 2823-2830

    • DOI

      10.1210/en.2011-2161

    • Peer Reviewed
  • [Journal Article] Treatment with constitutive androstane receptor ligand during pregnancy prevents insulin resistance in offspring from high-fat diet-induced obese pregnant mice2012

    • Author(s)
      Masuyama H, Hiramatsu Y
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 303(2) Pages: E293-E300

    • DOI

      10.1152/ajpendo.00167.2012

    • Peer Reviewed
  • [Journal Article] Antitumor effects of novel shorter truncated insulin-like growth factor l receptors2012

    • Author(s)
      Ojima Y, Hongo A, Liu Y, Zhu L, Kusumoto T, Nakamura K, Seki N, Kodama J, Hiramatsu Y
    • Journal Title

      Cancer Biol Ther

      Volume: 13(7) Pages: 559-566

    • Peer Reviewed
  • [Journal Article] Role of emmprin in endometrial cancer2012

    • Author(s)
      Nakamura K, Kodama J, Hongo A, Hiramatsu Y
    • Journal Title

      BMC Cancer

      Volume: 12 Pages: 1-11

    • DOI

      10.1186/1471-2407-12-191

    • Peer Reviewed
  • [Journal Article] Altered arterial stiffness in male-to-female trans- sexuals undergoing hormonal treatment2012

    • Author(s)
      Sharula, Chebib Chekir, Emi Y, Arai F, Kikuchi Y, Sasaki A, Matsuda M, Shimizu K, Tabuchi K, Kamada Y, Hiramatsu Y, Nakatsuka M
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 38(6) Pages: 932-940

    • DOI

      10.1111/j.1447-0756.2011.01815.x

    • Peer Reviewed
  • [Journal Article] 糖尿病, 耐糖能異常2012

    • Author(s)
      平松祐司
    • Journal Title

      臨床婦人科産科

      Volume: 66(5) Pages: 289-292

  • [Journal Article] 妊娠糖尿病の診断と管理2012

    • Author(s)
      平松祐司
    • Journal Title

      産婦実際

      Volume: 61(7) Pages: 1023-1028

  • [Journal Article] 妊娠糖尿病の定義と新しい診断基準2012

    • Author(s)
      平松祐司
    • Journal Title

      Modern Physician

      Volume: 32(8) Pages: 935-938

  • [Journal Article] 妊娠中のインスリン機能とアディポサイトカイン2012

    • Author(s)
      洲脇尚子, 平松祐司
    • Journal Title

      日本産科婦人科栄養・代謝研究会誌

      Volume: 18 Pages: 12-13

    • Peer Reviewed
  • [Journal Article] PCOS合併妊娠の耐糖能異常と周産期予後2012

    • Author(s)
      澤田麻里, 増山 寿, 鎌田泰彦, 松田美和, 清水恵子, 瀬川友功, 平松祐司, 中塚幹也
    • Journal Title

      日本産科婦人科栄養・代謝研究会誌

      Volume: 18 Pages: 51-52

    • Peer Reviewed
  • [Journal Article] 妊娠糖尿病と妊婦健診の今後2012

    • Author(s)
      平松祐司
    • Journal Title

      公衆衛生

      Volume: 76(10) Pages: 787-790

    • Peer Reviewed
  • [Journal Article] 妊娠中のアディポサイトカインとインスリン抵抗性ー耐糖能異常, 妊娠高血圧症候群の病態への関与と新たな治療標的の検討2012

    • Author(s)
      増山 寿
    • Journal Title

      日産婦誌

      Volume: 64(11) Pages: 2279-2289

    • Peer Reviewed
  • [Journal Article] 新旧GDM診断基準による周産期合併症発現率の変化2012

    • Author(s)
      延本悦子, 沖本直輝, 井上誠司, 瀬川友功, 増山 寿, 平松祐司, 杉山 隆, 日下秀人, 豊田長康
    • Journal Title

      糖尿病と妊娠

      Volume: 12(1) Pages: 50-53

    • Peer Reviewed
  • [Journal Article] 妊娠糖尿病の現状2012

    • Author(s)
      平松祐司
    • Journal Title

      Islet Equality

      Volume: 1(3) Pages: 2-3

  • [Journal Article] The role of hepatocyte growth factor activator inhibitor (HAI)-1 and HAI-2 in endometrial cancer2011

    • Author(s)
      Nakamura K, Hongo A, Kodama J, Hiramatsu Y
    • Journal Title

      Int J Cancer

      Volume: 128(11) Pages: 2613-2624

    • DOI

      10.1002/ijc.25606

    • Peer Reviewed
  • [Journal Article] Retinol-binding protein 4 and insulin resistance in preeclampsia2011

    • Author(s)
      Masuyama H, Inoue S, Hiramatsu Y
    • Journal Title

      Endocrine Journal

      Volume: 58(1) Pages: 47-53

    • URL

      https://www.jstage.jst.go.jp/article/endocrj/58/1/58_K10E-288/_pdf

    • Peer Reviewed
  • [Journal Article] Increased arterial stiffness in mildly-hypertensive women with polycystic ovary syndrome2011

    • Author(s)
      Sasaki A, Emi Y, Matsuda M, Sharula, Kamada Y, Chekir C, Hiramatsu Y, Nakatsuka M
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 37(5) Pages: 402-411

    • DOI

      10.1111/j.1447-0756.2010.01375.x

    • Peer Reviewed
  • [Journal Article] Fat accumulation in adipose tissues as a risk factor for the development of endometrial cancer2011

    • Author(s)
      Nakamura K, Hongo A, Kodama J, Hiramatsu Y
    • Journal Title

      Oncol Rep

      Volume: 26(1) Pages: 65-71

    • DOI

      10.3892/or.2011.1259

    • Peer Reviewed
  • [Journal Article] Effects of intermittent high glucose on BeWo choriocarcinoma cells in culture2011

    • Author(s)
      Masumoto A, Takamoto N, Masuyama H, Akahori Y, Inoue S, Hiramatsu Y
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 37(10) Pages: 1365-1375

    • DOI

      10.1111/j.1447-0756.2011.01539.x

    • Peer Reviewed
  • [Journal Article] 新FIGO分類(2009年)を用いた子宮 体 癌症例 の 検討2011

    • Author(s)
      西田 傑, 中村圭一郎, 久保光太郎, 黒川晴菜, 斎藤雅子, 長谷川徹, 光井 崇, 丹羽家泰, 今福紀章, 福島千加子, 楠本知行, 関 典子, 本郷淳司, 児玉順一, 平松祐司
    • Journal Title

      現 代 産婦人 科

      Volume: 60(2) Pages: 275-278

    • Peer Reviewed
  • [Journal Article] 妊娠糖尿病の新基準と最新エビデンス 妊娠糖尿病の新国際診断基準とわが国の対応2011

    • Author(s)
      平松祐司
    • Journal Title

      産婦実際

      Volume: 60(6) Pages: 811-819

  • [Journal Article] 新しい妊娠糖尿病診断基準と今後の対応2011

    • Author(s)
      平松祐司
    • Journal Title

      日本産科婦人科学会東京地方部会会誌

      Volume: 60(1) Pages: 7-12

    • Peer Reviewed
  • [Journal Article] 新時代を迎えた妊娠糖尿病2011

    • Author(s)
      平松祐司
    • Journal Title

      日本医事新報

      Volume: 4552 Pages: 48-49

    • Peer Reviewed
  • [Journal Article] 妊娠中のアディポサイトカインの動態とインスリン抵抗性への関与.日本産科婦人科栄養2011

    • Author(s)
      増山 寿, 赤堀洋一郎, 岸本佳子, 沖本直輝, 井上誠司, 瀬川友功, 平松祐司
    • Journal Title

      代謝研究会誌

      Volume: 17(1) Pages: 37-38

    • Peer Reviewed
  • [Journal Article] 妊娠糖尿病の新しい診断基準確 立 と今後 の 対応2011

    • Author(s)
      平松祐司
    • Journal Title

      糖 尿 病と妊 娠

      Volume: 11(1) Pages: 12-17

    • Peer Reviewed
  • [Journal Article] 多施設における妊娠糖尿病の新しい診断基準を用いた臨床統計2011

    • Author(s)
      中林正雄, 清水一紀, 平松祐司, 大森安恵, 加治屋昌子, 穴澤園子, 和栗雅子, 川崎 英二, 杉山 隆
    • Journal Title

      糖尿病と妊娠

      Volume: 11(1) Pages: 85-92

    • Peer Reviewed
  • [Journal Article] 糖尿病の新診断基準と今後の対応2011

    • Author(s)
      平松祐司
    • Journal Title

      月刊 糖尿病

      Volume: 3(10) Pages: 14-19

  • [Journal Article] アディポサイトカインとインスリン抵抗性2011

    • Author(s)
      増山 寿, 平松祐司
    • Journal Title

      月刊 糖尿病

      Volume: 3(10) Pages: 44-50

  • [Journal Article] 耐糖能 異 常と母 乳 栄養2011

    • Author(s)
      平松祐司, 杉山和歌菜, 増山 寿
    • Journal Title

      月 刊 糖尿 病

      Volume: 3(10) Pages: 113-118

  • [Journal Article] 妊娠糖尿病2011

    • Author(s)
      平松祐司
    • Journal Title

      岡山医学会雑誌

      Volume: 123(3) Pages: 243-245

    • Peer Reviewed
  • [Journal Article] 糖尿病の 母 児に与 え る影響2011

    • Author(s)
      平松祐司, 延本悦子, 増山 寿
    • Journal Title

      周 産期医 学

      Volume: 41(12) Pages: 1563-1566

  • [Presentation] Pregnancy and Gestational Diabetes Mellitus「Problems in diabetic pregnancy, now and the future2012

    • Author(s)
      Yuji Hiramatsu
    • Organizer
      9th International Diabetes Federation Western Pacific Region Congress & 4th Scientific Meeting of the Asian Association for the Study of Diabetes
    • Place of Presentation
      Kyoto International Conference Center
    • Year and Date
      20121124-27
  • [Presentation] 妊娠糖尿病2012

    • Author(s)
      平松祐司
    • Organizer
      第48回日本周産期, 新生児医学会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      20120708-10
  • [Presentation] 「妊娠とインスリン抵抗性」妊娠中のアディポサイトカインとインスリン抵 抗性ー耐糖能異常, 妊娠高血圧症候群の病態への関与と新しい治療標的の検討ー2012

    • Author(s)
      増山 寿
    • Organizer
      第64回日本産科婦人科学会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2012-04-14
  • [Presentation] 糖尿病の診断基準とHbA1cの標準化ー妊娠糖尿病の定義と診断基準の改訂2011

    • Author(s)
      平松祐司
    • Organizer
      第45回糖尿病学の進歩
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      20110218-19
  • [Presentation] Insulin resistance and adipocytokines in gestational diabetes millitus and preeclampsia

    • Author(s)
      Hisashi Masuyama, Yuji Hiramatsu
    • Organizer
      Insulin resistance and adipocytokines in gestational diabetes millitus and preeclampsia
  • [Book] 妊娠糖尿病.糖尿病最新の治療2013-2015(岩本安彦, 羽田勝計, 門脇 孝編)2013

    • Author(s)
      平松祐司
    • Total Pages
      73-75
    • Publisher
      南江堂, 東京
  • [Book] 妊娠糖尿病の定義・診断基準の変遷.「妊娠と糖尿病」母児管理のエッセンス, (難波光義, 杉山 隆編)2013

    • Author(s)
      平松祐司
    • Total Pages
      72-76
    • Publisher
      金芳堂, 京都
  • [Book] 新旧GDM診断基準による臨床像の変化.「妊娠と糖尿病」母児管理のエッセンス(難波光義, 杉山 隆編)2013

    • Author(s)
      平松祐司, 増本由美, 延本悦子
    • Total Pages
      81-84
    • Publisher
      金芳堂, 京都
  • [Book] 基礎研究の進歩.「妊娠と糖尿病」母児管理のエッセンス(難波光義, 杉山 隆編)2013

    • Author(s)
      増山 寿, 平松祐司
    • Total Pages
      91-95
    • Publisher
      金芳堂, 京都
  • [Book] 妊婦の糖代謝異常.科学的根拠に基づく糖尿病診療ガイドライン2013, 日本糖尿病学会編2013

    • Author(s)
      平松祐司
    • Total Pages
      217-232
    • Publisher
      南江堂, 東京
  • [Book] 妊娠糖尿病.代謝, 内分泌疾患診療 最新ガイドライン(門脇 孝, 下村伊一郎編)2012

    • Author(s)
      平松祐司
    • Total Pages
      51-56
    • Publisher
      総合医学社, 東京
  • [Book] 女性と糖尿病.女性を診る際に役立つ知識(武谷雄二編)2012

    • Author(s)
      平松祐司
    • Total Pages
      166-173
    • Publisher
      新興医学出版社, 東京
  • [Book] 妊娠と糖尿病.産婦人科学レビュー2011-最新主要文献と解説2011

    • Author(s)
      平松祐司
    • Total Pages
      33-38
    • Publisher
      総合医学社, 東京
  • [Book] 妊娠糖尿病の定義と診断基準の改訂.糖尿病学の進歩 2011, 日本糖尿病学会編2011

    • Author(s)
      平松祐司
    • Total Pages
      236-240
    • Publisher
      診断と治療社, 東京

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Published: 2015-06-25  

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