Analysis of pain induced mechanism after trigeminal nerve injury

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390461
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Niigata University
• Principal Investigator: SEO KENJI 新潟大学, 医歯学系, 教授 (40242440)
• Co-Investigator(Kenkyū-buntansha): MAEDA Takeyasu 新潟大学, 医歯学系, 教授 (40183941) ; FUJIWARA Naoshi 新潟大学, 医歯学系, 教授 (70181419) ; TERUMITSU Makoto 新潟大学, 医歯学系, 准教授 (60401767) ; TSURUMAKI Tatsuru 新潟大学, 医歯学系, 助教 (10345522) ; TANAKA Yutaka 新潟大学, 医歯学総合病院, 講師 (50323978) ; YOSHIKAWA Hiroyuki 新潟大学, 医歯学総合病院, 医員 (20547575) ; KURATA Shigenobu 新潟大学, 医歯学系, 助教 (20464018)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: trigeminal nerve / nerve injury / regeneration / BDNF / Semaphrin-3A

Outline of Final Research Achievements

When peripheral nerve is injured, the some local factors can be produced and affect the regeneration. Brain derived neurotrophic factor BDNFwas released from fibroblasts in the vicinity of the injury site, and its quantity increased within 24 hours after the incidence of injury and decreased after that, resulting in the disappearance. When this BDNF was inactivated at the local site immediately after the injury, elongation of neurites and reconnection of the injured axons were inhibited. This inactivation also inhibited regeneration of mechanical touch sensation, and allodynia, which appeared after the nerve injury, was inhibited. As another factor, the existence of nerve growth inhibitory protein semaphoring-3A was observed after the nerve injury. These results suggested that local facilitator and inhibitory factors are induced at the local site of nerve injury, and these can affect the regeneration, resulting in the prognosis.

Free Research Field

歯科麻酔学