International comparison of genomic variations for prognostic factors in chronic kidney disease

2013 Fiscal Year Final Research Report

• Project/Area Number: 23406027
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Kidney internal medicine
• Research Institution: Nagoya University
• Principal Investigator: MATSUO Seiichi 名古屋大学, 医学(系)研究科(研究院), 教授 (70190410)
• Co-Investigator(Kenkyū-buntansha): MARUYAMA Shoichi 名古屋大学, 医学系研究科, 准教授 (10362253) ; YUZAWA Yukio 藤田保健衛生大学, 医学部, 教授 (00191479) ; SATO Waichi 名古屋大学, 医学部附属病院, 講師 (90508920) ; TSUBOI Naotake 名古屋大学, 医学部附属病院, 講師 (50566958) ; YASUDA Yoshinari 名古屋大学, 医学系研究科, 寄附講座准教授 (60432259) ; KATO Sawako 名古屋大学, 医学系研究科, 助教 (80625757)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: ゲノムDNAメチル化 / 末期腎不全 / コホート研究 / LUMA法 / 炎症 / 感染症

Research Abstract

Inflammation is an established mortality risk factor in chronic kidney disease (CKD) patients and infection may contribution to induce inflammation. Our collaborating Nephrology group in Sweden showed that inflamed uremic Caucasian patients had signs of global DNA hyper-methylation. We have investigated that DNA hyper-methylation is linked to inflammatory markers including a marker of bacterial infections in Japanese CKD patients.Global DNA hyper-methylation was associated with ferritin and procalcitonin as a marker of bacterial infection, suggesting that inflammation induced by subclinical bacterial infection promoted DNA methylation. Moreover, Global DNA hyper-methylation was associated with near future inflammatory status, suggesting a possible axis between hyper-methylation status and present as well as future inflammatory status.These results strongly suggest that to control infection and immune dysfunction due to uremia may be important to induce inflammation in CKD patients.

Research Products

• [Journal Article] A ray of light in the dark : alternative approaches to the assessment and treatment of ischemic nephropathy (2014)
  • Author(s): Tsuboi N, Maruyama S, Matsuo S, ImaiE
  • Journal Title: Nephrol Dial Transplant Volume: 29(2) Pages: 228-31
• [Journal Article] Geriatric nutritional risk index accurately predicts cardiovascular mortality in incident hemodialysis patients (2013)
  • Author(s): Takahashi H, Ito Y, Ishii H, Aoyama T, Kamoi D, Kasuga H, Yasuda K, MaruyamaS, Matsuo S, Murohara T, Yuzawa Y
  • Journal Title: Jcardiol Volume: S0914-5087(13)003 Pages: 52-3
• [Journal Article] Effects of Spironolactone in Peritoneal Dialysis Patients (2013)
  • Author(s): Ito Y, Mizuno M, Suzuki Y, Tamai H, Hiramatsu T, Ohashi H, Ito I, Kasuga H, Horie M, Maruyama S, Yuzawa Y, Matsubara T, Matsuo S. Long-Term
  • Journal Title: J Am Soc Nephrol.Epub
• [Journal Article] Comparison of Kidney Disease : Improving GlobalOutcomes and Acute Kidney Injury Network criteria for assessing patients in intensive care units (2013)
  • Author(s): Shinjo H, Sato W, Imai E, Kosugi T, Hayashi H, Nishimura K, Nishiwaki K, Yuzawa Y, Matsuo S, Maruyama S
  • Journal Title: Clin Exp Nephrol.. Epub
• [Journal Article] TGF-β1 promotes lymphangiogenesis during peritoneal fibrosis (2013)
  • Author(s): Kinashi H, Ito Y, Mizuno M, Suzuki Y, Terabayashi T, Nagura F, Hattori R, Matsukawa Y, Mizuno T, Noda Y, Nishimura H, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y
  • Journal Title: J Am SocNephrol Volume: 24(10) Pages: 1627-42
• [Journal Article] Lower serum albumin level is associated with higher fractional excretion of creatinine (2013)
  • Author(s): Horio M, Imai E, Yasuda Y, Watanabe T, Matsuo S.
  • Journal Title: ClinExpNephrol. Epub.
• [Journal Article] Serum-starved adipose-derivedstroma l cells ameliorate crescentic GN by promoting immunoregulatory macrophages (2013)
  • Author(s): Furuhashi K, Tsuboi N, Shimizu A, Katsuno T, Kim H, Saka Y, Ozaki T, Sado, Y, Imai E, Matsuo S, Maruyama S
  • Journal Title: J Am Soc Nephrol Volume: 24(4) Pages: 587-603
• [Journal Article] Clinical correlates of ambulatory BPmonitoring among patients with CKD (2013)
  • Author(s): Iimuro S, Imai E, Watanabe T, Nitta K, Akizawa T, Matsuo S, Makino H, Ohashi Y, Hishida A
  • Journal Title: Clin J AmSocNephrol Volume: 8(5) Pages: 721-30
• [Journal Article] Risk factors for increased left ventricularhypertro phy in patients with chronic kidney disease (2013)
  • Author(s): Nitta K, Iimuro S, Imai E, Matsuo S, Makino H, Akizawa T, Watanabe T, Ohashi Y, Hishida A
  • Journal Title: Clin Exp Nephrol Volume: 17(5) Pages: 730-42
• [Journal Article] Clinical findings on ANCA-associated renal vasculitis from the Japan RPGN registry obtained via a questionnairesurvey (2013)
  • Author(s): Yamagata K, Usui J, Sugiyama H, Nitta K, Wada T, Muso E, Arimura Y, Koyama A, Makino H, Matsuo S
  • Journal Title: ClinExpNephrol Volume: 17(5) Pages: 646-9
• [Journal Article] Association of cardiac valvular calcifications and C-reactive protein withcardiovascular mortality in incidenthemodialy sis patients : a Japanese cohort study (2013)
  • Author(s): Takahashi H, Ishii H, Aoyama T, Kamoi D, Kasuga H, Ito Y, Yasuda K, Tanaka M, Yoshikawa D, Maruyama S, Matsuo S, Murohara T, Yuzawa Y
  • Journal Title: Am J Kidney Dis Volume: 61(2) Pages: 254-61
• [Journal Article] GFR estimationusingstanda rdized serum cystatin C in Japan (2013)
  • Author(s): Horio M, Imai E, Yasuda Y, Watanabe T, Matsuo S
  • Journal Title: Am J Kidney Dis Volume: 61(2) Pages: 197-203
• [Journal Article] Performance of GFR equations in Japanese subjects (2013)
  • Author(s): Horio M, Imai E, Yasuda Y, Watanabe T, Matsuo S
  • Journal Title: Clin Exp Nephrol Volume: 17(3) Pages: 352-8
• [Journal Article] A decade after the KDOQI CKD guidelines : a perspective from Japan (2012)
  • Author(s): Imai E, Yasuda Y, Matsuo S
  • Journal Title: Am J Kidney Dis Volume: 60(5) Pages: 729-30
• [Journal Article] Effects of carperitide on contrast-induced acute kidney injury with a minimum volume of contrast in chronic kidney disease patients (2012)
  • Author(s): Okumura N, Hayashi M, Imai E, Ishii H, Yoshikawa D, Yasuda Y, Goto M, Matsuo S, Oiso Y, Murohara T
  • Journal Title: Nephron Extra Volume: 2(1) Pages: 303-10
• [Journal Article] DNA hypermethylation and inflammatory markers in incident Japanese dialysis patients (2012)
  • Author(s): Lindholm B, Stenvinkel P, Ekström TJ, Luttropp K, Yuzawa Y, Yasuda Y, Tsuruta Y, Maruyama S
  • Journal Title: Nephron Extra Volume: 2(1) Pages: 159-168
• [Journal Article] Combined values of serum albumin, C-reactive protein and body mass index at dialysis initiation accurately predicts long-termmortal ity (2012)
  • Author(s): Takahashi R, Ito Y, Takahashi H, Ishii H, Kasuga H, Mizuno M, Suzuki Y, Yuzawa Y, Maruyama S, Murohara T, Imai E, Matsuo S
  • Journal Title: AmJNephrol Volume: 36(2) Pages: 136-43
• [Journal Article] Completeremission within 2 years predicts a good prognosis aftermethylprednisolone pulse therapy in patients with IgA nephropathy (2012)
  • Author(s): Tatematsu M, Yasuda Y, Morita Y, Sakamoto I, Kurata K, Naruse T, Yamamoto R, Tsuboi N, Sato W, Imai E, Matsuo S, Maruyama S
  • Journal Title: Clin ExpNephrol Volume: 16(6) Pages: 883-91
• [Journal Article] Percutaneous coronary intervention with bare metal stent vs.drug-eluting stent in hemodialysis patients (2012)
  • Author(s): Ishii H, Toriyama T, Aoyama T, Takahashi H, Tanaka M, Yoshikawa D, Hayashi M, Yasuda Y, Maruyama S, Matsuo S, Matsubara T, Murohara T
  • Journal Title: Circ J Volume: 76(7) Pages: 1609-15
• [Journal Article] Glomerular hyperfiltration in prediabetes and prehypertension (2012)
  • Author(s): Okada R, Yasuda Y, Tsushita K, Wakai K, Hamajima N, Matsuo S
  • Journal Title: NephrolDialTranspla Volume: 27(5) Pages: 1821-5
• [Journal Article] Validation of the equations for estimating daily sodium excretion from spot urine in patients with chronic kidney disease (2011)
  • Author(s): Imai E, Yasuda Y, Horio M, Shibata K, Kato S, Mizutani Y, Imai J, Hayashi M, Kamiya H, Oiso Y, Murohara T, Maruyama S, Matsuo S
  • Journal Title: Clin Exp Nephrol Volume: 15(6) Pages: 861-7
• [Journal Article] Association of adiponectin with carotidarteriosc lerosis in predialysis chronic kidney disease (2011)
  • Author(s): Hayashi M, Shibata R, Takahashi H, Ishii H, Aoyama T, Kasuga H, Yamada S, Ohashi K, Maruyama S, Matsuo S, Ouchi N, Murohara T, Toriyama T
  • Journal Title: Am J Nephrol Volume: 34(3) Pages: 249-55
• [Presentation] Neutrophil/Lymphocyte Ratio as a Predictor of Cardiovascular Events in Japanese Patients Starting Renal Replacement Therapy (2013)
  • Author(s): Sawako Kato
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta(U.S.A.)
  • Year and Date: 2013-11-09
• [Presentation] 新規透析導入患者における脈圧と平均血圧の検討 (2013)
  • Author(s): 加藤佐和子
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京都千代田区, 東京国際フォーラム
  • Year and Date: 2013-05-11
• [Presentation] Characteristics ofJapa nese dialysis patients evaluated by estimated dietary protein intake and serum phosphorus (2012)
  • Author(s): Sawako Kato
  • Organizer: The 30th annual meeting of the International Society of Blood Purification
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2012-09-07
• [Presentation] GNRI in Japanese incident dialysis patients (2012)
  • Author(s): Sawako Kato
  • Organizer: The 16thInterna tional Congress on Nutrition and Metabolism in Renal Disease
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2012-06-30
• [Presentation] 新規透析導入患者における抗炎症分子としてのHDL コレステロールの役割 (2012)
  • Author(s): 加藤佐和子
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: 東京都千代田区, 東京国際フォーラム
  • Year and Date: 2012-05-11
• [Presentation] Impact of Subclinical Bacterial Infection on Epigenetic DNA Methylation in Japanese CKD Stage 5 Patients (2011)
  • Author(s): Sawako Kato
  • Organizer: 44rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia, PA
  • Year and Date: 2011-11-12
• [Presentation] Association ofAdi pokines with Cardiovascular Mortality in Patients on Hemodialysis (2011)
  • Author(s): Shoichi Maruyama
  • Organizer: 44rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelph ia, PA
  • Year and Date: 2011-11-10
• [Presentation] Is epigenetic DNAhyper -methylation linked to chronicinfla mmation in Japanese dialysispatients? (2011)
  • Author(s): Sawako Kato
  • Organizer: The 29th annual meeting of the International Society of BloodPurif ication
  • Place of Presentation: Beijing, China
  • Year and Date: 2011-09-10
• [Presentation] Association between changes in vascular stiffness after initiation of maintenance dialysis therapy and low level of intact PTH level (2011)
  • Author(s): Sawako Kato
  • Organizer: The 47th annual meeting of the European Renal Association-European Dialysis Transplant Association
  • Place of Presentation: Prague, Czech
  • Year and Date: 2011-06-25