Roles of ERK1/2 in neuronal migration and positioning during cerebral cortical development

2014 Fiscal Year Final Research Report

• Project/Area Number: 23500421
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: National Defense Medical College
• Principal Investigator: IMAMURA OSAMU 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 准教授 (40534954)
• Co-Investigator(Kenkyū-buntansha): TAKISHIMA Kunio 防衛医科大学校, 医学教育部医学科専門課程, 教授 (50531365) ; DATEKI Minori 防衛医科大学校, 医学教育部医学科専門課程, 助教 (00415879)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 大脳皮質形成 / シグナル伝達 / 細胞移動 / ノックアウトマウス / 神経回路

Outline of Final Research Achievements

The mitogen activated protein kinases, Erk1 and Erk2 (Erk1/2) are critical intracellular signaling intermediates in proliferation and differentiation. Erk1/2 is also essential for memory and learning in the brain. In this study, to elucidate the roles of Erk1/2 in the developing mouse cerebral cortex, we generated neuron-specific Erk1/2 double knockout mice using Synapcine-Cre mice and found that Erk signaling is required for radial migration, neuronal positioning and neuronal circuit formation.

Free Research Field

総合領域