Contribution of post-translational modifications of tubulins in neuronal morphogenesis

2014 Fiscal Year Final Research Report

• Project/Area Number: 23500443
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: University of Fukui
• Principal Investigator: KONISHI Yoshiyuki 福井大学, 工学(系)研究科(研究院), 准教授 (00382838)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 微小管 / 翻訳後修飾 / 軸索 / 極性 / 樹状突起 / チュブリン / シグナル伝達

Outline of Final Research Achievements

Microtubules play central roles in the regulation of cellular morphology. It could receive region dependent regulation within the cell, which is especially important in the regulation of complicated neuronal cell shape. In this project, we investigated the role of two types of post-translational modifications of tubulins, tyrosination and polyglutamylation in the regulation of neuronal structure. Especially, we found that polyglutamylation regulate the dendritic distribution of neurofilaments. In addition to these tubulin modifications, we investigated the neuronal subtype dependent regulation of morphogenesis.

Free Research Field

神経化学