2013 Fiscal Year Final Research Report
Elucidation of circadian and seasonal variation of thrombosis-related factor in older peoples
| Project/Area Number |
23500850
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Yoshimitsu 大阪国際大学, 人間科学部, 教授 (70144566)
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| Project Period (FY) |
2011 – 2013
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| Keywords | VWF / ADAMTS13 / 季節変動 / 日内変動 / 老化 |
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| Research Abstract |
VWF revealing a thrombophilic action as a molecular glue and ADAMTS13 revealing an antithrombogenic action by the function of specifically cutting VWF were adopted and circadian variation and seasonal variation thereof and senescent influences modifying them were investigated in platelet thrombosis using healthy older peoples and college boys as subjects. As a result, VWF showed high values for older peoples in all seasons and time zones and a tendency of the highest value in the morning in winter was observed. In contrast, ADAMTS13 showed low values for older peoples and a tendency of the lowest value of activity especially in the morning in winder was observed. These results suggest easier incidence of platelet thrombosis in sporting activity in winder, particularly in the morning, for older peoples.
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