2013 Fiscal Year Final Research Report
Analysis of p53 72SNP in stress responce
| Project/Area Number |
23501267
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Kyoto University |
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Principal Investigator |
HABU Toshiyuki 京都大学, 放射線生物研究センター, 助教 (70346071)
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| Project Period (FY) |
2011 – 2013
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| Keywords | p53 / SNP / HPV |
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| Research Abstract |
Single nucleotide polymorphism(SNP) affect disease and stress responses. To address the relationship between SNP and stress response, p53 72SNP was introduced in human cell line using genetic recombination method. These cells showed the different responses under DNA damage agents although these cells have same genetic background. These results indicated that p53 SNP affect physiological output and these approach are useful for SNP study.
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Research Products
(17 results)
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[Journal Article] The moyamoya disease susceptibility variant RNF213 1 R4810K induces genomic instability by mitotic abnormality2013
Author(s)
Hitomi T, Habu T, Kobayashi H, Okuda H, Harada HK, Osafune K, Taura D, Sone M, Asaka I, Ameku T, Watanabe A, Kasahara T, Sudo T, Shiota F, Hashikata H, Takagi Y, Morito D, Miyamoto S, Nakao K, Koizumi A
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 439(4)
Pages: 419-426
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[Journal Article] Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients2013
Author(s)
Hitomi T, Habu T, Kobayashi H, Okuda H, Harada KH, Osafune K, Taura D, Sone M, Asaka I, Ameku T, Watanabe A, Kasahara T, Sudo T, Shiota F, Hashikata H, Takagi Y, Morito D, Miyamoto S, Nakao K, Koizumi A
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 438(1)
Pages: 13-19
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