2013 Fiscal Year Final Research Report
Pathological analysis of cryoglobulinemia and glomerulonephropathy in experimental Capillaria hepatica infection
| Project/Area Number |
23580415
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Azabu University |
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Principal Investigator |
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| Research Collaborator |
上家 潤一
相原 尚之
山田 萌
樫村 茜
市川 いおり
高橋 映理佳
若林 伸
CHAMBERS J. K.
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| Project Period (FY) |
2011 – 2013
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| Keywords | クリオグロブリン / 免疫病理 / 寄生虫 / 病理 |
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| Research Abstract |
This study established the mouse model of experimental cryoglobulinemia induced by oral administration of Capillaria hepatica eggs, and revealed that the induced cryoglobulinemia was consistent with type II cryoglobulinemia which was characterized by monoclonal IgM rheumatoid factor (RF) and polyclonal IgA. The experimental study showed that selective proliferation of IgM RF-producing B-1a cells induced by stimulation of the parasites occurred in the early phase of the cryoglobulinemia, and also demonstrated that following factors or events are essential for the onset of this cryoglobulinemia: 1) the splenic B-1a cells as IgM RF-producing cell, 2) proliferation of B-1a cells, 3) the specific parasitic antigen as a trigger of IgM production, 4) IL-5 as a cryoglobulinemia promoting factor.
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