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2013 Fiscal Year Final Research Report

Possible Involvement of ion Channels in atrial fibrillation

Research Project

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Project/Area Number 23590256
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General physiology
Research InstitutionAkita University

Principal Investigator

IINO Kenji  秋田大学, 医学部, 講師 (30400485)

Co-Investigator(Kenkyū-buntansha) WATANABE Hiroyuki  秋田大学, 大学院医学系研究科, 准教授 (80323145)
ITO Hiroshi  秋田大学, 大学院医学系研究科, 教授 (10232464)
KOYAMA Takashi  秋田大学, 医学部, 助教 (50508273)
Project Period (FY) 2011 – 2013
Keywords心房細動 / イオンチャネル / TRPチャネル
Research Abstract

Studies of transient receptor potential (TRP) channels have significantly extended our knowledge regarding the molecular basis of Ca2+ signals in cardiac myocytes. The functional significance of cardiac TRP channels is likely connected to the alteration of membrane potential or Ca2+ entry into a noncontractile compartment, where gene expression responsible for various cardiac diseases is induced. This study highlights some aspects of TRP channels with anticipated roles in cardiac disease. Evidence suggests that (a) increased activities of TRPC1, TRPC3, or TRPC6 are involved in the development of cardiac hypertrophy, where these TRPC channels act as unique sensors for a wide range of hypertrophic stimuli, and (b) increased activities of TRPM4,7 and TRPC3,6 are involved in atrial remodeling or mechanical stretch on cardiac arrhythmia. Ultimately, TRP channels may become novel pharmacological targets in the treatment of human cardiac disease.

  • Research Products

    (4 results)

All 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results) (of which Invited: 2 results)

  • [Journal Article] Possible involvement of TRP channels in cardiac hypertrophy and arrhythmia Curent Topics2013

    • Author(s)
      Watanabe H, Iino K, Ohba T, Ito H
    • Journal Title

      Medical Chemistry

      Volume: 13 Pages: 283-294

    • Peer Reviewed
  • [Journal Article] Sildenafil prevents the up-regulation of TRPCs in the development of cardiomyocytes hypertrophy2013

    • Author(s)
      Kiso H, Ohba T, Iino K, Terada Y, Murakami M, Ono K, Watanabe H, Ito H
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 436 Pages: 514-518

    • Peer Reviewed
  • [Presentation] TRP channel and cardiac hypertrophy2013

    • Author(s)
      Watanabe H
    • Organizer
      The23th Scientific Congress of KSH
    • Place of Presentation
      Korea
    • Year and Date
      2013-05-11
    • Invited
  • [Presentation] Transient receptor potential (TRP) Channel and Hypertensive Heart Disease2013

    • Author(s)
      Watanabe H
    • Organizer
      The23th Scientific Congress of KSH
    • Place of Presentation
      Korea
    • Year and Date
      2013-05-10
    • Invited

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Published: 2015-07-16  

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