2013 Fiscal Year Final Research Report
Analysis of novel chemokine receptor variant in cancer-associated inflammatory microenvironment
| Project/Area Number |
23590406
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Reiko 千葉大学, 真菌医学研究センター, 助教 (60143319)
AOKI Ichiro 横浜市立大学, 医学研究科, 教授 (00184028)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAGI Etsuko 横浜市立大学, 附属病院, 准教授 (40275053)
MIYAGI Yohei 神奈川県立がんセンター, がん分子病態研究部門, 部門長 (00254194)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 卵巣癌 / 炎症 / ケモカイン |
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| Research Abstract |
We examined pathophysiology of impaired CXCR3 signaling in endometriosis-associated ovarian cancer (EAOC) under IFN-g enriched microenvironment.
The expression of CXCL4, a ligand of CXCR3-B, was gradually suppressed as cancer developed from endometriosis lesion. We confirmed that the responsible cell type expressing CXCL4 was macrophage. Interestingly, infiltrating macrophages in endometriosis were CD68 (+) CXCL4 (+) whereas those in EAOC were CD163 (+) CXCL4 (-). Furthermore, we found that suppressor of cytokine signaling (SOCS) was severely suppressed in these IFN-g-high EAOC.
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[Journal Article] Intratumoral peripheral small papillary tuft : A diagnostic clue of renal tumors associated with Birt-Hogg-Dubé syndrome2014
Author(s)
Kuroda N, Furuya M, Nagashima Y, Gotoda H, Moritani S, Kawakami F, Imamura Y, Bando Y, Takahashi M, Kanayama H, Ota S, Michal M, Hes O, Nakatani Y.
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Journal Title
Ann Diagn Pathol
Volume: vol18
Pages: 171-6
DOI
Peer Reviewed
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[Journal Article] Multifocal and microscopic chromophobe renal cell carcinomatous lesions associated with 'capsulomas' without FCLN gene abnormality2013
Author(s)
Sugimoto K, Takasawa A, Ichimiya S, Murata M, Kimura H, Aoyama T, Gille JJ, Kuroda N, Shimizu H, Hasegawa T, Sawada N, Furuya M, Nagashima Y
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Journal Title
Pathol Int
Volume: vol 63
Pages: 510-515
DOI
Peer Reviewed
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[Journal Article] Pulmonary Cysts of Birt-Hogg-Dubé Syndrome : A Clinico- pathologic and Immunohistochemical Study of 9 Families2012
Author(s)
Furuya M, Tanaka R, Koga S, Yatabe Y, Gotoda H, Takagi S, Hsu YH, Fujii T, Okada A, Kuroda N, Moritani S, Mizuno H, Nagashima Y, Nagahama K, Hiroshima K, Yoshino I, Nomura F, Aoki I, Nakatani Y.
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Journal Title
Am J Surg Pathol
Volume: vol 36
Pages: 589-600
DOI
Peer Reviewed
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