Research for mechanisms of ulcerative colitis associated colorectal neoplasia development.

2013 Fiscal Year Final Research Report

• Project/Area Number: 23590410
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Dokkyo Medical University
• Principal Investigator: FUJIMORI TAKAHIRO 獨協医科大学, 医学部, 教授 (30095385)
• Project Period (FY): 2011 – 2013
• Keywords: 潰瘍性大腸炎関連腫瘍 / 前癌状態 / 癌化高危険群 / REG 1α / DNMT1/3b / IL-22 / STAT3

Research Abstract

Pathological diagnosis of colorectal neoplasia associated with ulcerative colitis (UC) is difficult and diagnostic error can cause a significant impact on treatment options for the patient. Neoplasia associated with UC were two common types and three rare types. However, the efficacy of current morphological diagnosis remains unsatisfactory in early detection of these tumors. In order to overcome these difficulties, we assess the immunohistochemical analysis of P53, DNMT, ER, REG and neuroendocrine differentiation. Immunohistochemistry was useful tools for pathological discrimination between UC associated neoplasia and inflammatory regenerative epithelium, whereas, to settle these issues further studies based on the molecular markers, needed be carried out.

Research Products

• [Journal Article] Micropapillary pattern at the invasive front and its association with unresectable colorectal carcinomas (2013)
  • Author(s): Akimoto N, Fujimori T, Mitomi H, Ichikawa K, Tomita S, Tatsuguchi A, Fujimori S, Naito Z, Sakamoto C
  • Journal Title: Disease Markers Volume: 35 Pages: 451-455
  • DOI: 10.1155/2013/851623
  • Peer Reviewed
• [Journal Article] Digestive disease management in Japan : A report on The 6th diagnostiv pathology summer fest in 2012 (2013)
  • Author(s): Ichikawa K, Fujimori T, Moriya T, Ochiai A, Yoshinaga S, Kushima R, Nagahama R, Ohkura Y, Tanaka S, Ajioka Y, Hirata I, Tanaka M, Hoshihara Y, Kinoshita Y, Sasano H, Iwashita A, Tomita S, Hirota S, Yao T, Fujii S, Matsuda T, Ueno H, Ishikawa Y, Takubo K, Fukushima N, Sugai Y, Iwafuchi M, Imura J, Manabe T, Fukuyama M
  • Journal Title: Digestion Volume: 88 Pages: 153-160
  • DOI: 10.1159/000355330
  • Peer Reviewed
• [Journal Article] Manganese superoxide dismutase plays an important role in the inflammatory process and predicts disease severity and activity in patients with ulcerative colitis (2013)
  • Author(s): Ikumoto T, Hayashi S, Tomita S, Miwa S, Mitomi H, Fujimori T, Imura J
  • Journal Title: APMIS
  • DOI: 10.1111/apm.12192
  • Peer Reviewed
• [Journal Article] Histologival assessment of intra-and inter-institutional reliabilities in detection of desmoplastic reaction in biopsy specimens of early colorectal carcinomas (2013)
  • Author(s): Okamoto Y, Fujimori T, Ohkura T, Sugai T, Arai T, Wataneabe G, Wada R, Ueno H, Togashi K, Yao T, Kushima R, Mitomi H, Tomita S, Igarashi Y, Ichikawa K
  • Journal Title: Pathology International Volume: 63 Pages: 539-545
  • DOI: 10.1111/pin.12110
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of chromogranin A and p53 expression in ulcerative colitis- associated neoplasia : neuroendocrine differentiation as an early event in colitis-neoplasia sequence (2013)
  • Author(s): Shigaki K, Mitomi H, Fujimori T, Ichikawa K, Tomita S, Imura J, Fujii S, Itabashi M, Kameoka S, Sahara R, Takenoshita S
  • Journal Title: Human Pathology Volume: 44 Pages: 2393-2399
  • DOI: 10.1016/j.humpath.2013.06.008
  • Peer Reviewed
• [Journal Article] Analysis of the anatomic subsites, gender and age in unresctable advanced colorectal carcinomas in Tochigi, Japan suggests a shift in location towards the right side colon in elderly patients treated with cetuximab (2013)
  • Author(s): Tanaka T, Ichikawa K, Maruoka T, Tomita S, Ueda H, Yamaguchi T, Shida Y, Kato H, Nagata H, Kubota K, Akimoto N, Sakamoto C, Imura J, Arita M, Tanaka H, Okamoto Y, Igarashi T, Fujimori T
  • Journal Title: Molecular and clinical Oncology Volume: 1 Pages: 291-296
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of the DNA methyltransferase 3b expression is associated with significant improvements in the discrimination of ulcerative colitis-associated neoplastic lesions (2013)
  • Author(s): Ueda H, Tanaka H, Ichikawa K, Itabashi M, Kameoka S, Fujii S, Saito N, Kimura R, Shida Y, Fujimori Y, Ohtake S, Tomita S, Imura J, Yasuda Y, Tanigawa N, Uchiyama K, Fujimori T
  • Journal Title: Surgery Today Volume: 43 Pages: 1275-1280
  • DOI: 10.1007/s00595-012-0456-6
  • Peer Reviewed
• [Journal Article] IgG4-related plasmacytic enteropathy mimicking ulcerative colitis (2012)
  • Author(s): Imura J, Fujimori T
  • Journal Title: International Journal of Surgical Pathology Volume: 20 Pages: 59
  • Peer Reviewed
• [Journal Article] DMBT1 is a novel gene induced by IL-22 ulcerative colitis (2011)
  • Author(s): Fukui H, Sekikawa A, Tanaka H, Fujimori T, Katake Y, Fujii S, Ichikawa K, Tomita S, Imura J, Chiba T, Fujimori Tm
  • Journal Title: Inflammatory Bowel Disease Volume: 17 Pages: 1177-1188
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of REG Iαexpression in ulcerative colitis-associated neoplastic lesions (2011)
  • Author(s): Tanaka H, Fukui H, Fujii S, Sekikawa A, Yamagishi H, Ichikawa K, Tomita S, Imura J, Yasuda Y, Chiba T, Fujimori T
  • Journal Title: Digestion Volume: 83 Pages: 204-209
  • Peer Reviewed
• [Presentation] Invasive micropapillary carcinomaはDukes'C大腸癌における難知性大腸癌の予測因子となりうる (2013)
  • Author(s): 秋元直彦, 藤盛孝博, 他
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌
  • Year and Date: 2013-06-08
• [Presentation] Crohn病に回腸癌を併発した1例 (2013)
  • Author(s): 丸岡喬, 藤盛孝博, 他
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌
  • Year and Date: 2013-06-08
• [Presentation] リン酸化EGFRを用いたLHPにおけるSSA/PとHPの検討 (2013)
  • Author(s): 岡本健太郎, 藤盛孝博, 他
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌
  • Year and Date: 2013-06-08
• [Presentation] 大腸pSM癌の切除後の長期予後他施設共同検討(結腸vs直腸)(第2報) (2013)
  • Author(s): 池松弘朗, 藤盛孝博, 他
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: さっぽろ芸文館
  • Year and Date: 2013-06-07
• [Presentation] 大腸癌K-ras遺伝子変異検索におけるパイロシークエンシングの精度の検討 (2013)
  • Author(s): 池松弘朗, 藤盛孝博, 他
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: さっぽろ芸文館
  • Year and Date: 2013-06-07
• [Book] Desmoplastic reaction in biopsy specimens of T1 stage colorectal cancer plays a critical role in defining the level of sub-mucosal invasion
  • Author(s): Tomita S, Fujii S, Fujimori T
  • Publisher: In Tech