2014 Fiscal Year Final Research Report
The control mechanism of immune response by MD molecules
| Project/Area Number |
23590564
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Aichi Medical University (2013-2014)
The University of Tokyo (2011-2012) |
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Principal Investigator |
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| Research Collaborator |
YAMAKAWA Natsuko
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | MD-1 / 脂質 / B細胞 |
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| Outline of Final Research Achievements |
We found that a serum lipid and lipid-receptor induced signal works as an activator of immunology, importantly. A soluble protein MD-1 associated with RP105, which is one of the similar molecules of Toll-like receptors (TLRs) on immune cells. MD-1 was found in serum by our established ELISA assay. We also found the possibility that the serum MD-1 regulated a surplus immune response by a controlling the lipid activation.
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| Free Research Field |
免疫学
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