Evaluating state of renal disease by analyzing urine

2016 Fiscal Year Final Research Report

• Project/Area Number: 23590702
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Tokyo Medical University (2014-2016); National Defense Medical College (2011-2013)
• Principal Investigator: ODA TAKASHI 東京医科大学, 医学部, 教授 (90531187)
• Project Period (FY): 2011-04-28 – 2017-03-31
• Keywords: 尿 / 腎疾患 / 疾患活動性 / 尿沈渣 / 半月体

Outline of Final Research Achievements

Urine tests are non-invasive and may reflect the general condition of the whole kidney better than do renal biopsy results, so the urinary sediments of patients who underwent kidney biopsy in our hospital were analyzed in relation to their renal histological conditions. Claudin1 is a tight-junction protein specifically expressed by epithelial cells of Bowman’s capsule. Claudin1-, CD68- and NE-positive cell counts were higher in patients with glomerular crescents (especially cellular crescents) than in patients without crescents, and relative levels of mRNA for CD68 and the M2 MΦ markers were also higher in patients with glomerular crescents. These data suggest that IF staining for claudin1, CD68 and NE in urinary sediments and the relative levels of mRNA for CD68 and M2 MΦ markers in urinary sediments are useful for evaluating the state of glomerular diseases.

Free Research Field

腎臓内科