The association of sub-clinical atherosclerosis and estimated glomelular filtration rate with albuminuria among general Japanese.

2014 Fiscal Year Final Research Report

• Project/Area Number: 23590791
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Shiga University of Medical Science (2011, 2014); Osaka Kyoiku University (2012-2013)
• Principal Investigator: KADOTA Aya 滋賀医科大学, アジア疫学研究センター, 特任准教授 (60546068)
• Co-Investigator(Kenkyū-buntansha): UESHIMA Hirotsugu 滋賀医科大学, アジア疫学研究センター, 特任教授 (70144483) ; MIURA Katsuyuki 滋賀医科大学, 医学部, 教授 (90257452)
• Co-Investigator(Renkei-kenkyūsha): FUJIYOSHI Akira 滋賀医科大学, 医学部, 特任助教 (10567077) ; OHKUBO Takayoshi 帝京大学, 医学部, 教授 (60344652) ; KADOWAKI Sayaka 滋賀医科大学, 医学部, 客員助教 (60510344) ; SEKIKAWA Akira 滋賀医科大学, 医学部, 客員准教授 (10216525)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 潜在性動脈硬化症 / 腎機能障害 / 微量アルブミン尿 / 疫学研究

Outline of Final Research Achievements

We investigated to clarify the association of subclinical atherosclerosis and estimated glomelular filtration rate (eGFR) with albuminuria among general Japanese. 860 Japanese men aged 40 to 74 years were randomly selected from Kusatsu City, Japan. Carotid atherosclerosis was assessed by ultra-sonography and the baPWV were investigated using an automated machine with a standardized method. Both serum creatinine and urine albumin were measured enzymaticaly.
Both eGFR and urine albumin were related with subclinical atherosclerosis assessed by carotid atherosclerosis (IMT and plaque) and baPWV. When subclinical atherosclerosis was assessed with the combination of eGFR and urine albumin, we found that the subclinical atherosclerosis was progressed with albuminuria>=30mg/gCr even though eGFR>=60ml/min/1.72m2. In the multivariate adjusted regression model, we found that urine albumin related with the subclinical atherosclerosis independently from eGFR.

Free Research Field

糖尿病・循環器疫学