Development of genomics-based prophylaxis strategy for gastric mucosal injury induced by anti-platelet agents

2013 Fiscal Year Final Research Report

• Project/Area Number: 23590913
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: FURUTA TAKAHISA 浜松医科大学, 医学部附属病院, 准教授 (10303546)
• Co-Investigator(Kenkyū-buntansha): SUGIMOTO Mitsushige 浜松医科大学, 医学部附属病院, 助教 (80397398) ; OGAWA Noriyoshi 浜松医科大学, 医学部附属病院, 講師 (80308618) ; TAKEUCHI Kazuhiko 浜松医科大学, 医学部, 準教授 (00419425) ; MATSUYAMA Yukihiro 浜松医科大学, 医学部, 教授 (20312316) ; NANBA Hiroki 浜松医科大学, 医学部, 教授 (60198405) ; UMEMURA Kazuo 浜松医科大学, 医学部, 教授 (40232912)
• Project Period (FY): 2011 – 2013
• Keywords: 低用量アスピリン / H. pylori / 胃粘膜傷害 / 遺伝子多型 / SLCO1B1

Research Abstract

Pharmacogenomics associated with the gastric mucosal injury induced by low dose aspirin (LDA) was investigated. We measured the four SNPs associated with metabolism of aspirin in patients treated with LDA. We analyzed the association of such SNPs with gastric mucosal injury with reference to H. pylori infection. The relative risk of gastric ulcer in patients with SLCO1B1 (rs4149056) TT genotype was 3.2 folds as high as that of those with C allele. The results suggest that measurement of SNP of SLCO1B1 could be the predictive marker of gastric mucosa injury induced by LDA.

Research Products

• [Journal Article] Prevention ofgastricmucosal injuryinduced by anti-platelet drugs by famotidine (2014)
  • Author(s): Uotani T, Sugimoto M, Nishino M, Ichikawa H, Sahara S, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T
  • Journal Title: J Clin Pharmacol Volume: (Epub ahead of print)
  • DOI: 10.1002/jcph.284
• [Journal Article] Rapid Automated Genotyping of CYP2C19 and the Helicobacter pylori 23S rRNA Gene in Gastric Juice (2013)
  • Author(s): Furuta T, Soya Y, Sugimoto M, Nishino M, Yamade M, Uotani T, Kodaira C, Sahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Maekawa M, Watanabe H, Umemura K
  • Journal Title: Journal of GHR Volume: 2 Pages: 403-407
• [Journal Article] Association of gastric mucosal injury severity with platelet function and gastric pH during low-dose aspirin treatment (2013)
  • Author(s): Nishino M, Sugimoto M, Uotani T, Yamade M, Sahara S, Ichikawa H, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T
  • Journal Title: Digestion Volume: 88(2) Pages: 79-86
• [Journal Article] Antiplatelet drugs are a risk factor for esophageal mucosal injury (2013)
  • Author(s): Sugimoto M, Uotani T, Nishino M, Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T
  • Journal Title: Digestion Volume: 87(4) Pages: 281-9
• [Journal Article] Ability of Rabeprazole to Prevent Gastric Mucosal Damage from Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype (2012)
  • Author(s): Uotani T, Sugimoto M, Nishino M, Kodaira C, Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K, Tanaka T, Umemura K, Watanabe H, Miyajima H, Furuta T
  • Journal Title: ClinGastroenterolHepatol Volume: 10(8) Pages: 879-885
• [Journal Article] Impactofacidinhibitiononesophagealmucosalinjury inducedbylow-doseaspirin (2012)
  • Author(s): Sugimoto M,NishinoM,KodairaC,YamadeM,UotaniT,Ikuma M,Furuta T
  • Journal Title: Digestion Volume: 85(1)(Epub2011 Nov24) Pages: 9-17
• [Journal Article] The Acid-Related Symptoms Research Group. Investigation of Pretreatment Prediction of Proton Pump Inhibitor (PPI)-Resistant Patients with Gastroesophageal Reflux Disease and the Dose Escalation Challenge of PPIs :-TORNADO study-a Multicenter Prospective Study by the ARS (Acid-Related Symptoms) Research Group in Japan (2011)
  • Author(s): Furuta T, ShimataniT, Sugimoto M, IshiharaS, FujiwaraY, Kusano M, Koike T, Hongo M, Chiba T, Kinoshita Y
  • Journal Title: J Gastroenterol Volume: 46(11) Pages: 1273-1283
• [Journal Article] Characteristics of non-erosive gastroesophageal reflux disease refractory to proton pump inhibitor therapy (2011)
  • Author(s): Sugimoto M, Nishino M, Kodaira C, Yamade M, Uotani T, Ikuma M, Umemura K, Furuta T
  • Journal Title: World J Gastroenterol Volume: 17(14) Pages: 1858-65
• [Journal Article] Preventive Effects of Lansoprazole and Famotidine on Gastric Mucosal Injury Induced by Low-Dose Aspirin in Helicobacter pylori-Negative Healthy Volunteers (2011)
  • Author(s): Nishino M, Sugimoto M, Kodaira C, Yamade M, Uotani T, Shirai N, Ikuma M, Tanaka T, Sugimura H, Hishida A, Furuta T
  • Journal Title: J Clin Pharmacol Volume: 51(7) Pages: 1079-86
• [Journal Article] Impact of Acid Inhibition on Esophageal Mucosal Injury Induced by Low-Dose Aspirin (2011)
  • Author(s): Sugimoto M, Nishino M, Kodaira C, Yamade M, Uotani T, Ikuma M, Furuta T
  • Journal Title: Digestion Volume: 85(1) Pages: 9-17