2013 Fiscal Year Final Research Report
Analysis of pathophysiology of EBV-positive T- or NK-lymphoproliferative diseases and development of new treatment strategy
| Project/Area Number |
23591375
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ARAI Ayako 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (70359678)
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| Co-Investigator(Kenkyū-buntansha) |
IMADOME Ken-ichi 国立成育医療研究センター, 母児感染研究部, 室長
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| Project Period (FY) |
2011 – 2013
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| Keywords | T,NK細胞リンパ腫 / EBウイルス / NF-ｋB / 血液腫瘍学 / マウスモデル |
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| Research Abstract |
We performed the research in order to elucidate the molecular mechanisms of EBV-positive T or NK lymphoproliferative diseases (EBV-T/NK-LPDs) development, and to establish the new treatment strategy for the disorders. First, we established the xenograft model of EBV-T/NK-LPDs and published the results in 2011. In addition, we performed in vitro EBV infection assay and found that EBV induced NF-kB-mediated anti-apoptotic signals in T and NK cells. NF-kB was constitutively activated in EBV-positive T- or NK-cells, not only in the cell lines, but in patients cells. Suppression of NF-kB by proteasome inhibitor bortezomib induces anti-tumor effects on EBV-T/NK-LPD not only in vitro but also in vivo. NF-kB may contribute to the development of EBV-T/NK-neoplasms and represents an attractive therapeutic target for the diseases. We reported the results at EHA meeting in 2013, and we have submitted the manuscript to the journal in 2014.
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[Journal Article] Expression of multidrug resistance 1 gene in B-cell lymphomas : association with follicular dendritic cells2013
Author(s)
Yagi K, Yamamoto K, Umeda S, Abe S, Suzuki S, Onishi I, Kirimura S, Fukayama M, Arai A, Kitagawa M, Kurata M
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Journal Title
Histopathology
Volume: 62
Pages: 414-20
DOI
Peer Reviewed
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[Journal Article] Recurrence of chronic active Epstein-Barr virus infection from donor cells after achieving complete response through allogeneic bone marrow transplantation2012
Author(s)
Arai A, Imadome K, Wang L, Wu N, Kurosu T, Wake A, Yamamoto H, Ota Y, Harigai M, Fujiwara S, Miura O
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Journal Title
Int Medicine
Volume: 51(7)
Pages: 777-82
Peer Reviewed
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