2013 Fiscal Year Final Research Report
The development of novel therapy with microRNA in gastric cancer
| Project/Area Number |
23591931
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOYOOKA Shinichi 岡山大学, 医歯薬学総合研究科, 教授 (30397880)
ASANO Hiroaki 岡山大学, 大学病院, 助教 (70534775)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 胃癌 / マイクロＲＮＡ / 遺伝子治療 |
|---|
| Research Abstract |
The genetic alteration of microRNA 34b/c in gastric cancers has been studied. The microRNA 34b/c is considered to work under p53, the tumor suppressor gene, and have tumor suppressor effects. The promoter region was highly methylated and the expression was suppressed in most gastric cancer cell lines. The similar methylation was also found in primary gastric cancer tissues of the patients. And gene transfection of mircroRNA 34b/c in the gastric cancer cells showed the suppression of tumor growth which insinuated that this microRNA would be useful for gene therapy to the gastric cancers.
|
