2015 Fiscal Year Final Research Report
Induction of hormone-secreting cells from pituitary stem cells
| Project/Area Number |
23592121
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
Hojo Masato 京都大学, 医学研究科, 非常勤講師 (60372588)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAGWYAMA Ryoichiro 京都大学, ウイルス研究所, 教授 (80224369)
MIYAMOTO Susumu 京都大学, 医学研究科, 教授 (70239440)
|
|---|
| Project Period (FY) |
2011-04-28 – 2016-03-31
|
| Keywords | 下垂体 / Notch / bHLH / Hes1 / Hes5 |
|---|
| Outline of Final Research Achievements |
The pituitary development requires the control of proliferation and differentiation of progenitors. Molecular mechanisms of adenohypophysis development are much better understood, but little is known about mechanisms that regulate neurohypophysis development.
The aim of this study was to clarify the role of Hes genes, known as Notch effectors, in neurohypophysis development. We have found that Hes1 and Hes5 control not only maintenance of progenitor cells but also pituicyte versus neuron fate specification during neurohypophysis development.
|
| Free Research Field |
発生
|
