2013 Fiscal Year Final Research Report
The mechanism of carcinogenesis of choriocarcinoma with glycosyltransferases for hyperglycosylated hCG
| Project/Area Number |
23592445
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagoya University |
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Principal Investigator |
YAMAMOTO Eiko 名古屋大学, 医学部附属病院, 講師 (10432262)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBATA Kiyosumi 名古屋大学, 医学系研究科, 准教授 (90335026)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 絨毛癌 / 糖転移酵素 / GnT-IVa / C2GnT-1 |
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| Research Abstract |
The structures of sugar chains of hCG are quite different in trophoblastic neoplasia compared with normal pregnancy and hydatidiform mole, and it is because of N-acetylglucosaminyltransferase IVa (GnT-IVa)and core 2 beta-1, 6-N-acetylglucosaminyltransferase (C2GNT). The expression of GnT-IVa and C2GNT was strong in choriocarcinoma and invasive mole, but very weak in normal placenta and hydatidiform mole. The two glycosyltransferases involoved in promoting of invasion ability in choriocarcinoma. The result of immunoprecipitation suggested that Gnt-IVa promotes invasion ability via glycosylation of beta1 integrin. Luiferase assay suggested that cRel may regulate transcription of GnT-IVa via binding to the promoter of GnT-IVa.
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Author(s)
Kondo S, Demachi-Okamura A, Hirosawa T, Maki H, Fujita M, Uemura Y, Akatsuka Y, Yamamoto E, Shibata K, Ino K, Kikkawa F, Kuzushima K
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Journal Title
Hum Immunol
Volume: 74
Pages: 1103-1110
Peer Reviewed
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Author(s)
Mitsui H, Shibata K, Mano Y, Suzuki S, Umezu T, Mizuno M, Yamamoto E, Kajiyama H, Kotani T, Senga T, Kikkawa F
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Journal Title
Clin Exp Metastasis
Volume: 30
Pages: 731-740
Peer Reviewed
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