2015 Fiscal Year Final Research Report
3-dimensional and histo-pathological examination on the bone augmentation using bone growth factor and bone substitute
| Project/Area Number |
23592891
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | University of the Ryukyus (2014-2015)
Kagoshima University (2011-2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA NORIFUMI 鹿児島大学, 大学院医歯学総合研究科, 教授 (60217875)
TAMATSU YUICHI 鹿児島大学, 大学院医歯学総合研究科, 准教授 (80266569)
MATSUYAMA TAKASHI 鹿児島大学, 大学院医歯学総合研究科, 准教授 (40253900)
ARASAKI AKIRA 琉球大学, 大学院医学研究科, 教授 (00175960)
GOTO TAKAHIRO 琉球大学, 医学部附属病院, 助教 (60578912)
MAKISHI SHOKO 琉球大学, 医学部附属病院, 助教 (60457679)
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| Project Period (FY) |
2011-04-28 – 2016-03-31
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| Keywords | 骨造成 / 骨補填材 / 骨成長因子 |
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| Outline of Final Research Achievements |
In this present study, the effects of bone growth factor and bone substitute on the bone augmentation by three-dimensional (3-D) and histopathological evaluation were examinated. 3-D evaluation was used cone bean CT and histopathological was HE staining and TRAP or ALP immunostaining. The bone augmentation was performed by the materials using autologous bone alone and the mixed bone growth factor (PRP or CGF) and a bone substitutes (HA or HA + b-TCP or b-TCP). The bone augmentation using only bone growth factor was not sufficiently observed on the 3-D and histopathological evaluation. On the other hand, the bone augmentation using the materials mixed bone growth factor and bone substitute is observed enough.
The bone resorption on this bone was small than that on the bone using the autologous bone alone.
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| Free Research Field |
口腔外科
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