• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

The effect of IL-22 on biological activity of periodontal ligament cells

Research Project

  • PDF
Project/Area Number 23593076
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontal dentistry
Research InstitutionHyogo Medical University

Principal Investigator

OHYAMA hideki  兵庫医科大学, 医学部, 准教授 (90280685)

Co-Investigator(Kenkyū-buntansha) TERADA Nobuyuki  兵庫医科大学, 医学部, 名誉教授 (50150339)
NAKASHO Keiji  兵庫医科大学, 医学部, 教授 (00217712)
YAMADA Naoko  兵庫医科大学, 医学部, 講師 (10319858)
YAMANEGI Koji  兵庫医科大学, 医学部, 講師 (00434944)
Project Period (FY) 2011 – 2013
Keywords歯根膜細胞 / IL-22 / 石灰化誘導
Research Abstract

This study focused on the biological effects of IL-22 on periodontal ligament (PDL) cells as part of studies to assess the involvement of IL-22 in periodontal disease. We found that IL-22 treatment had no effect on the proliferative response in PDL cells. Meanwhile, IL-22 precipitated mineralized nodule formation and induced gene expressions of RUNX2, MSX2 and osteocalcin in PDL cells, suggesting that IL-22 enhances the mineralized matrix-forming activities of PDL cells. In addition, the production of several cytokines including IL-11, IL-8 and CCL2 was upregulated by IL-22 treatment of PDL cells in a dose-dependent manner.IL-22 has the potential to promote mineralizing activity in PDL cells and to develop appropriate regenerative therapy.

  • Research Products

    (8 results)

All 2013 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Decreased expression of VE-cadherin and claudin-5 and increased phosphorylation of VE-cadherin in vascular endothelium in nasal polyps2013

    • Author(s)
      Yukitatsu Y, Hata M, Yamanegi K, Yamada N, Ohyama H, Nakasho K, Kojima Y, Oka H, Tsuzuki K, Sakagami M, Terada N
    • Journal Title

      Cell Tissue Res

      Volume: Jun;352(3) Pages: 647-57

    • DOI

      10.1007/s00441-013-1583-0

    • Peer Reviewed
  • [Journal Article] T-cell Responses Involved in the Predisposition to Periodontal Disease : Lessons from Immunogenetic Studies of Leprosy2012

    • Author(s)
      Ohyama H, Kato-Kogoe N, Takeuchi-Hatanaka K, Yamanegi K, Yamada N, Nakasho K, Matsushita S, Terada N
    • Journal Title

      J Clin Cell Immunol

      Volume: S1 Pages: 005

    • DOI

      10.4172/2155-9899.S1-005

    • Peer Reviewed
  • [Journal Article] The promotional effect of IL-22 on mineralization activity of periodontal ligament cells2012

    • Author(s)
      Kato-Kogoe N, Nishioka T, Kawabe M, Kataoka F, Yamanegi K, Yamada N, Hata M, Yamamoto T, Nakasho K, Urade M, Terada N, Ohyama H
    • Journal Title

      Cytokine

      Volume: Jul;59(1) Pages: 41-8

    • DOI

      10.1016/j.cyto.2012.03.024

    • Peer Reviewed
  • [Presentation] IL-22/TNF-αの単独および共刺激によって誘導されるヒト歯根膜由来細胞の生物学的活性2013

    • Author(s)
      川辺睦記,浦出雅裕,大山秀樹
    • Organizer
      第67回日本口腔科学会学術集会
    • Place of Presentation
      栃木県総合文化センター(栃木県)
    • Year and Date
      2013-05-23
  • [Presentation] Th17細胞産生性サイトカインが血管石灰化に及ぼす影響2012

    • Author(s)
      大山秀樹
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2012-04-27
  • [Presentation] IL-22がヒト歯根膜由来細胞の石灰化ノジュール形成に及ぼす影響2011

    • Author(s)
      大山秀樹
    • Organizer
      第54回日本歯周病学会春季学術大会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2011-05-28
  • [Presentation] IL-22存在下においてヒト歯根膜由来細胞が発現する遺伝子の網羅的解析2011

    • Author(s)
      川辺睦記
    • Organizer
      第54回日本歯周病学会春季学術大会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2011-05-27
  • [Book] Leprosy-Science working towards dignity2011

    • Author(s)
      Hideki Ohyama
    • Total Pages
      97-107
    • Publisher
      Tokai University Press

URL: 

Published: 2015-07-16   Modified: 2018-02-02  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi