Longevity function of trehalose and its effects on amyloid formation

2014 Fiscal Year Final Research Report

• Project/Area Number: 23617041
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrated Nutrition Science
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: HONDA Shuji 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (40100127)
• Co-Investigator(Kenkyū-buntansha): 本田 陽子 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (90399460)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: トレハロース / 老化 / 寿命 / 腎臓 / 脳

Outline of Final Research Achievements

Trehalose is a disaccharide of glucose found in diverse organisms. We previously found that treatment of the nematode Caenorhabditis elegans with trehalose extended the mean lifespan by over 30%. To clarify whether trehalose delays the aging processes and lengthens lifespan in mammals, we examined the effects of trehalose treatment on aging and lifespan of mice. Trehalose treatment slightly extended the lifespan of C57 BL/6J male mice and suppressed the age-associated leakage of albumin into the urine. Trehalose treatment also suppressed the age-associated increase in neuronal ubiquitinated inclusions of senescence-accelerated mice (SAM)-P10. These results suggest that trehalose retards the aging processes in mammals.

Free Research Field

基礎老化学