2012 Fiscal Year Final Research Report
Fundamental study on developing heart failure treatment targeting the central nervous system.
| Project/Area Number |
23650213
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurophysiology and muscle physiology
|
|---|
| Research Institution | National Cardiovascular Center Research Institute |
|---|
Principal Investigator |
SIRAI Mikiyasu 独立行政法人国立循環器病研究センター, 研究所, 部長 (70162758)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
AKIYAMA Tsuyoshi 独立行政法人国立循環器病研究センター, 研究所, 室長 (70202554)
TSUCHIMOCHI Hirotsugu 独立行政法人国立循環器病研究センター, 研究所, 室長 (60379948)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TO Seikon 独立行政法人国立循環器病研究センター, 研究所, 非常勤研究員 (90590646)
MORIMOTO Satio 九州大学, 医学研究科, 助教授 (50202362)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 心不全 / 心筋梗塞 / 拡張型心筋症 / 心臓自律神経活動 / 心臓マイクロダイアリシス / 心拍変動 / グレリン |
|---|
| Research Abstract |
Cardiac parasympathetic activity, which has a cardioprotective effect, was assessed in a mouse model of dilated cardiomyopathy (DCM) using a microdialysis technique. We found that the adrenergic mechanism for controlling cardiac parasympathetic activity was suppressed at the central nervous system level. Percutaneous ghrelin injection for one month augmented cardiac parasympathetic activity and attenuated sympathetic activity and then improved myocardial remodeling and contractility, reducing the high mortality rate associated with DCM. One dose of ghrelin prevented the acute and sustained increase in cardiac sympathetic tone after myocardial infarction and then reduced the high mortality rate attributable to sudden heart failure in the rat.
|
Research Products
(39 results)
-
-
-
-
-
-
-
[Journal Article] Medetomidine, an α2-adrenergic agonist, activates cardiac vagal nerve through modulation of baroreflex control.2012
Author(s)
Shimizu S, Akiyama T, Kawada T, Sata Y, Mizuno M, Kamiya A, Shishido T, Inagaki M, Shirai M, Sano S, Sugimachi M.
-
Journal Title
Circ. J.
Volume: 76
Pages: 152-159
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Docking protein Gab1 is an essential component of postbatal angiogenesis after ischemia via HGF/c-Met signaling.2011
Author(s)
Shioyama W, Nakaoka Y, Higuchi K, Minami T, Taniyama Y, Kidoya H, Sonobe T, Hashimoto T, Shirai M, Takakura N, Morishita R, Yamaguchi-Takihara K, Kodama T, Hirano T, Mochizuki N, Komuro I.
-
Journal Title
Circ. Res.
Volume: 108
Pages: 664-675
DOI
Peer Reviewed
-
[Journal Article] Centrally administered ghrelin activates cardiac vagal nerve in anesthetized rabbits.2011
Author(s)
Shimizu S, Akiyama T, Kawada T, Sonobe T, Kamiya A, Shishido T, Tokudome T, Hosoda H, Shirai M, Kangawa K, Sugimachi M.
-
Journal Title
Auton. Neurosci.
Volume: 162
Pages: 60-65
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
