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2011 Fiscal Year Final Research Report

Development of novel drug delivery system for micro RNA nucleic biomedicine using exosome from human cultured cells

Research Project

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Project/Area Number 23650626
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Clinical oncology
Research InstitutionHiroshima University

Principal Investigator

TAHARA Hidetoshi  広島大学, 大学院・医歯薬学総合研究科, 教授 (00271065)

Co-Investigator(Renkei-kenkyūsha) OCHIYA Takahiro  独立行政法人国立がん研究センター, がん転移研究室, 室長 (60192530)
KURODA Masahiko  東京医科大学, 医学部, 教授 (80251304)
Project Period (FY) 2011
Keywordsエクソソーム / マイクロRNA / ドラッグデリバリーシステム / がん
Research Abstract

We have developed Cd44-GFP expressing cells including normal and cancer cell lines to visualized exosomes. We also purified CD44-GFP labeled exosomes form those cells. We confirmed that CD44-GFP labeled exosomes cargo microRNA by adding these exosomes to the other cells. These tools should be useful for exosome derived DDS technology.

  • Research Products

    (5 results)

All 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] miR-22 represses cancer progressionby inducing cellular senescence2011

    • Author(s)
      D. Xu, F. Takeshita, Y. Hino, S. Fukunaga, Y. Kudo, A. Tamaki, J. Matsunaga, R. Takahashi, T. Takata, A. Shimamoto, T. Ochiya, H. Tahara
    • Journal Title

      J. Cell Biology

      Volume: 193 Pages: 409-442

    • Peer Reviewed
  • [Journal Article] Two unrelatedpatients with MRE11A mutationsand Nijmegen breakage syndrome-like severe microcephaly2011

    • Author(s)
      Y. Matsumoto, T. Miyamoto, H. Sakamoto, H. Izumi, Y. Nakazawa, T. Ogi, H. Tahara, S. Oku, A. Hiramoto, T. Shiiki, Y. Fujisawa, H. Ohashi, Y. Sakemi, S. Matsuura
    • Journal Title

      DNA Repair

      Volume: 10 Pages: 314-321

    • Peer Reviewed
  • [Presentation] Micro RNA profiling in senescent associated exosome2011

    • Author(s)
      中村亜由美、岡田恵、小坂展慶、落谷孝広、田原栄俊
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-24
  • [Presentation] Visualization of senescence secreted exosome.2011

    • Author(s)
      岡田恵、中村亜由美、小坂展慶、落谷孝広、田原栄俊
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-15
  • [Presentation] Senescent associated microRNAs analysis inexosomes2011

    • Author(s)
      Ayumi Nakamura, Nobuyoshi Kosaka, Aya Tamaki, Megumi Okada, TakahiroOchiya, Hidetoshi Tahara
    • Organizer
      Exosome and Microvesice
    • Place of Presentation
      Orland, USA
    • Year and Date
      2011-10-16

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Published: 2013-07-31   Modified: 2016-01-05  

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