2012 Fiscal Year Final Research Report
Regulation mechanism by hydrogen sulfide anion of electrophilesignaling
| Project/Area Number |
23651239
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | Kumamoto University |
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Principal Investigator |
AKAIKE Takaaki 熊本大学, 大学院・生命科学研究部, 教授 (20231798)
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| Co-Investigator(Kenkyū-buntansha) |
FUJII Shigemoto 熊本大学, 大学院・生命科学研究部, 助教 (00325333)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 硫化水素 / 親電子物質 / シグナル伝達 / 8-nitro-cGMP / S-グアニル化 |
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| Research Abstract |
In the cellular response to oxidative stress, electrophiles suchas 8-nitro-cGMP function as important signal mediators. In this study, we examined thereaction mechanism of hydrogen sulfide-related compounds with electrophiles to revealits role in the signal regulation. As a result, we found that hydrogen sulfide-relatedcompounds react with 8-nitro-cGMP to produce 8-SH-cGMP, and are involved in the regulationof electrophile signaling.
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[Journal Article] S-nitrosated α-1-acid glycoproteinkills drug-resistant bacteria and aidssurvival in sepsis2013
Author(s)
Watanabe K, Ishima Y, Akaike T, Sawa T,Kuroda T, Ogawa W, Watanabe H, SuenagaA, Kai T, Otagiri M, and Maruyana T
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Journal Title
FASEB J.
Volume: 27
Pages: 391-398
Peer Reviewed
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[Journal Article] Identification of and screening forhuman Helicobacter cinaedi infectionsand carriers via nested PCR2012
Author(s)
Oyama K, Khan S, Okamoto T, Fujii S, OnoK, Matsunaga T, Yoshitake J, Sawa T,Tomida J, Kawamura Y, and Akaike T
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Journal Title
J ClinMicrobiol
Volume: 50
Pages: 3893-3900
Peer Reviewed
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[Journal Article] Hydrogensulfide anion regulates redoxsignaling via electrophilesulfhydration.2012
Author(s)
Nishida M, Sawa T, Kitajima N, Ono K,Inoue H, Ihara H, Motohashi H, YamamotoM, Suematsu M, Kurose H, van der VlietA, Freeman BA, Shibata T, Uchida K,Kumagai Y, and Akaike T
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Journal Title
Nat Chem Bio
Volume: 8
Pages: 714-724
Peer Reviewed
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[Journal Article] a novel target ofHNF4α interacts with GRP78 andregulates endoplasmic reticulumstress-induced apoptosis inpancreatic β-cells2012
Author(s)
Sato Y, Hatta M, Karim MF, Sawa T, WeiF-Y, Sato S, Magnuson MA, Gonzalez FJ,Tomizawa K, Akaike T, Yoshizawa T, andYamagata K. Anks4b
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Journal Title
J Biol Chem.
Volume: 287
Pages: 23236-23245
Peer Reviewed
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[Journal Article] S-Guanylation of human serum albuminis a unique posttranslationalmodification and results in a novelclass of antibacterial agents2012
Author(s)
Ishima Y, Hoshino H, Shinagawa T,Watanabe K, Akaike T, Sawa T,Kragh-hansen U, Kai T, Watanabe H,Maruyama T, and Otagiri M.
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Journal Title
J PharmSci.
Volume: 101
Pages: 3222-3229
Peer Reviewed
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[Journal Article] Potential association of Helicobactercinaedi with atrial arrhythmia andatherosclerosis2012
Author(s)
Khan S, Okamoto T, Enomoto K, SakashitaN, Oyama K, Fujii S, Sawa T, Takeya M,Ogawa H, Yamabe H, and Akaike T
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Journal Title
Microbiol Immunol
Volume: 56
Pages: 145-154
Peer Reviewed
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[Journal Article] Vascular responses to 8-nitro-cyclicGMP in non-diabetic and diabetic mice2011
Author(s)
Tokutomi Y, Kataoka K, Yamamoto E, Nakamura T, Fukuda M, Nako H, Toyama K,Yi-Fei Dong Y-F, Ahmed KA, Sawa T,Akaike T, and Kim-Mitsuyama S
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Journal Title
Br J Pharmacol.
Volume: 162
Pages: 1884-1893
Peer Reviewed
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