2012 Fiscal Year Final Research Report
microRNA analysis as the predictive tool of the breast cancer treatment
| Project/Area Number |
23659183
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Tohoku University |
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Principal Investigator |
SASANO Hironobu 東北大学, 大学院・医学系研究科, 教授 (50187142)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIDA Takanori 東北大学, 大学院・医学系研究科, 准教授 (00292318)
SUZUKI Takashi 東北大学, 大学院・医学系研究科, 教授 (10261629)
MIKI Yasuhiro 東北大学, 災害科学国際研究所, 講師 (50451521)
ONO Katsuhiko 東北大学, 大学院・医学系研究科, 技術専門 職員 (80466531)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 乳癌 / microRNA / LIN28 / Ki-67 / HER2 |
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| Research Abstract |
A new molecular technique as a breast cancer diagnosis is attracting a great deal of attention. In this research, I clarified relation between miRNA expression and pathological biomarkers using breast cancer tissues. These main results of this research are as follows: 1) LIN28 correlated with let-7 family 2) Identification of miRNAs relatedwith Ki-67, which is proliferation marker. and 3) Identification of miRNAs related with HER2, which is targeting molecule for breast cancer therapy. The results from our research suggest the possibility of the miRNA analysis as an novel diagnosis tool for breast cancer.
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[Journal Article] LMTK3 is implicated in endocrine resistance via multiple signaling pathways2013
Author(s)
Stebbing J, Filipovic A, Lit LC, Blighe K, Grothey A, Xu Y, Miki Y, Chow LW, Coombes RC, Sasano H, Shaw JA, Giamas G
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Journal Title
Oncogene
Volume: (In press)
DOI
URL
Peer Reviewed
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[Journal Article] Androgenic pathway in triple negative invasive ductal tumors: Its correlation with tumor cell proliferation2013
Author(s)
McNamara KM, Yoda T, Miki Y, Chanplakorn N, Wongwaisayawan S, Incharoen P, Kongdan Y, Wang L, Takagi K, Mayu T, Nakamura Y, Suzuki T, Nemoto N, Miyashita M, Tamaki K, Ishida T, Ohuchi N, Sasano H
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Journal Title
Cancer Sci
Volume: 104(5)
Pages: 639-646
DOI
Peer Reviewed
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[Journal Article] An induction of microRNA, miR-7 through estrogen treatment in breast carcinoma2012
Author(s)
Masuda M, Miki Y, Hata S, Takagi K, Sakurai M, Ono K, Suzuki K, Yang Y, Abe E, Hirakawa H, Ishida T, Suzuki T, Ohuchi N, Sasano H
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Journal Title
URL
Peer Reviewed
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[Journal Article] Aromatase inhibitor treatment of breast cancer cells increases the expression of let-7f, a microRNA targeting CYP19A12012
Author(s)
Shibahara Y, Miki Y, Onodera Y, Hata S, Chan MS, Yiu CC, Loo TY, Nakamura Y, Akahira J, Ishida T, Abe K, Hirakawa H, Chow LW, Suzuki T, Ouchi N, Sasano H
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Journal Title
J Pathol
Volume: 227(3)
Pages: 357-366
DOI
Peer Reviewed
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[Journal Article] Oestrogen-induced genes in ductal carcinoma in situ: their comparison with invasive ductal carcinoma2012
Author(s)
Ebata A, Suzuki T, Takagi K, Miki Y, Onodera Y, Nakamura Y, Fujishima F, Ishida K, Watanabe M, Tamaki K, Ishida T, Ohuchi N, Sasano H
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Journal Title
Endocr Relat Cancer
Volume: 19(4)
Pages: 485-496
DOI
Peer Reviewed
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[Journal Article] Analysis of clinically relevant values of Ki-67 labeling index in Japanese breast cancer patients2012
Author(s)
Tamaki K, Ishida T, Tamaki N, Kamada Y, Uehara K, Miyashita M, Amari M, Tadano-Sato A, Takahashi Y, Watanabe M, McNamara K, Ohuchi N, Sasano H
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DOI
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