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2013 Fiscal Year Final Research Report

Development of combination methods with dendritic cells and novel chemokine products for preventing hepatocellular carcinoma recurrence

Research Project

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Project/Area Number 23659396
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionUniversity of Fukui

Principal Investigator

NAKAMOTO Yasunari  福井大学, 医学部, 教授 (40293352)

Project Period (FY) 2011 – 2013
Keywords癌 / 免疫学 / トランスレーショナルリサーチ / 動物 / 内科
Research Abstract

The current study was designed to develop the combination methods with dendritic cells and novel chemokine products for preventing the recurrence of hepatocellular carcinoma following the treatments. The methods of dendritic cell induction were modified using OK-432 and zinc, and the chemokine products were evaluated for the activation of the cancer immunity. Furthermore, the biological stability of the products was improved by recombinant technology. Collectively, the results indicated that the modified methods using both dendritic cells and the chemokine products may contribute to the reduction of hepatocellular carcinoma recurrence.

  • Research Products

    (25 results)

All 2014 2013 2012 2011

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (5 results)

  • [Journal Article] Gd-EOB-DTPA-enhanced magnetic resonance imaging and alpha-fetoprotein predict prognosis of early-stage hepatocellular carcinoma2014

    • Author(s)
      Yamashita T, Kitao A, Matsui O, Hayashi T, Nio K, Kondo M, Ohno N, Miyati T, Okada H, Yamashita T, Mizukoshi E, Honda M, Nakanuma Y, Takamura H, Ohta T, Nakamoto Y, Yamamoto M, Takayama T, Arii S, Wang XW, Kaneko S
    • Journal Title

      Hepatology

      Volume: (in press)

    • DOI

      10.1002/hep.27093.

    • Peer Reviewed
  • [Journal Article] Intractable Liver and Biliary Diseases Study Group of Japan : Multicenter validation study of anti-programmed cell death-1 antibody as a serological marker for type 1 autoimmune hepatitis2014

    • Author(s)
      Miyake Y, Yamamoto K, Matsushita H, Abe M, Takahashi A, Umemura T, Tanaka A, Nakamuta M, Nakamoto Y, Ueno Y, Saibara T, Takikawa H, Yoshizawa K, Ohira H, Zeniya M, Onji M, Tsubouchi H
    • Journal Title

      Hepatol. Res

      Volume: (in press)

    • DOI

      10.1111/hepr.12305.

    • Peer Reviewed
  • [Journal Article] In vivo immunological antitumoreffect of OK-432-stimulated dendritic cell transfer after radiofrequencyablation2014

    • Author(s)
      Nakagawa H, Mizukoshi E, Iida N, Terashima T, Kitahara M, Marukawa Y, KitamuraK, Nakamoto Y, Hiroishi K, Imawari M, Kaneko S
    • Journal Title

      Cancer Immunol Immunother

      Volume: 63 Pages: 347-356

    • DOI

      10.1007/s00262-013-1514-7.

    • Peer Reviewed
  • [Journal Article] Pathophysiological Decrease in the Regional Cerebral Blood Flow in Hashimoto's Encephalopathy : A Multiple-Case SPECT Study2014

    • Author(s)
      Muramatsu T, Ikawa M, Yoneda M, Sugimoto K, Matsunaga A, Yamamura O, Hamano T, Okazawa H, Nakamoto Y
    • Journal Title

      Eur Neurol

      Volume: 72 Pages: 13-19

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/24777056

    • Peer Reviewed
  • [Journal Article] Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma2013

    • Author(s)
      Yamashita T, Honda M, Nakamoto Y, Baba M, Nio K, Hara Y, Zeng SS, Hayashi T, Kondo M, Takatori H, Yamashita T, Mizukoshi E, Ikeda H, Zen Y, Takamura H, Wang XW, Kaneko S
    • Journal Title

      Hepatology

      Volume: 57 Pages: 1484-1497

    • DOI

      10.1002/hep.26168.

    • Peer Reviewed
  • [Journal Article] Increase in CD14+HLA-DR -/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis2013

    • Author(s)
      Arihara F, Mizukoshi E, Kitahara M, Takata Y, Arai K, Yamashita T, Nakamoto Y, Kaneko S
    • Journal Title

      Cancer Immunol. Immunother

      Volume: 62 Pages: 1421-1430

    • DOI

      10.1007/s00262-013-1447-1.

    • Peer Reviewed
  • [Journal Article] Correction : TNF-α and Tumor Lysate Promote the Maturation of Dendritic Cells for Immunotherapy for Advanced Malignant Bone and Soft Tissue Tumors2013

    • Author(s)
      Miwa S, Nishida H, Tanzawa Y, Takata M, Takeuchi A, Yamamoto N, Shirai T, Hayashi K, Kimura H, Igarashi K, Mizukoshi E, Nakamoto Y, Kaneko S, Tsuchiya H
    • Journal Title

      PLoS One (eCollection 2013.)

      Volume: 24 Pages: 8

    • DOI

      10.1371/annotation/7c0f14e6-cfba-4f5fb93d-1a149eaeec96

    • Peer Reviewed
  • [Journal Article] Detection of preclinically latent hyperperfusion due to stroke-like episodes by arterial spin-labeling perfusion MRI in MELAS patients2013

    • Author(s)
      Ikawa M1, Yoneda M, Muramatsu T, Matsunaga A, Tsujikawa T, Yamamoto T, Kosaka N, Kinoshita K, Yamamura O, Hamano T, Nakamoto Y, Kimura H
    • Journal Title

      Mitochondrion

      Volume: 13 Pages: 676-680

    • DOI

      10.1016/j.mito.2013.09.007.

    • Peer Reviewed
  • [Journal Article] Hashimoto's encephalopathy as a treatable adult-onset cerebellar ataxia mimicking spinocerebellar degeneration2013

    • Author(s)
      Matsunaga A, Ikawa M, Fujii A, Nakamoto Y, Kuriyama M, Yoneda M
    • Journal Title

      Eur. Neurol

      Volume: 69 Pages: 14-20

    • DOI

      10.1159/000342217.

    • Peer Reviewed
  • [Journal Article] TNF-α and tumor lysate promote the maturation of dendritic cells for immunotherapy for advanced malignant bone and soft tissue tumors2013

    • Author(s)
      Miwa S1, Nishida H, Tanzawa Y, Takata M, Takeuchi A, Yamamoto N, Shirai T, Hayashi K, Kimura H, Igarashi K, Mizukoshi E, Nakamoto Y, Kaneko S, Tsuchiya H
    • Journal Title

      PLoS One

      Volume: 7 Pages: e52926

    • DOI

      10.1371/journal.pone.0052926.

    • Peer Reviewed
  • [Journal Article] Clinical relevance and sequence analysis of the Helicobacter pylori dupA region from two areas in Japan with different gastric cancer risks2012

    • Author(s)
      Matsuda H, Ito Y, Suto H, Yamakawa A, Satomi S, Ohtani M Yamazaki Y, Kusaka Y, Shimabukuro Y, Kikuchi K, Keida Y, Azuma T, Nakamoto Y
    • Journal Title

      Immuno-Gatroenterology

      Volume: 1:2 Pages: 127-135

    • URL

      http://www.stmconnect.com/ig

    • Peer Reviewed
  • [Journal Article] Membrane-bound form of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma2012

    • Author(s)
      Marukawa Y, Nakamoto Y, Kakinoki K, Tsuchiyama T, Iida N, Kagaya T, Sakai Y, Naito M, Mukaida N, Kaneko S
    • Journal Title

      Cancer Gene Ther

      Volume: 19 Pages: 312-319

    • DOI

      10.1038/cgt.2012.3.

    • Peer Reviewed
  • [Journal Article] Nucleostemin in Injury-Induced Liver Regeneration2012

    • Author(s)
      Shugo H, Ooshio T, Naito M, Naka K, Hoshii T, Tadokoro Y, Muraguchi T, Tamase A, Uema N, Yamashita T, Nakamoto Y, Suda T, Kaneko S, Hirao A
    • Journal Title

      Stem Cells Dev

      Volume: 21 Pages: 3044-3054

    • DOI

      10.1089/scd.2011.0725.

    • Peer Reviewed
  • [Journal Article] Guideline on the use of new anticancer drugs for the treatment of Hepatocellular Carcinoma 2010 update2012

    • Author(s)
      Kaneko S, Furuse J, Kudo M, Ikeda K, Honda M, Nakamoto Y, Onchi M, Shiota G, Yokosuka O, Sakaida I, Takehara T, Ueno Y, Hiroishi K, Nishiguchi S, Moriwaki H, Yamamoto K, Sata M, Obi S, Miyayama S, Imai Y
    • Journal Title

      Hepatol. Res

      Volume: 42 Pages: 523-542

    • DOI

      10.1111/j.1872-034X.2012.00981.x.

    • Peer Reviewed
  • [Journal Article] Evaluation of systemic redox states in patients carrying the MELAS A3243G mutation in mitochondrial DNA2012

    • Author(s)
      Ikawa M, Arakawa K, Hamano T, Nagata M, Nakamoto Y, Kuriyama M, Koga Y, Yoneda M
    • Journal Title

      Eur. Neurol

      Volume: 67 Pages: 232-237

    • DOI

      10.1159/000336568.

    • Peer Reviewed
  • [Journal Article] Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization2011

    • Author(s)
      Nakamoto Y, Mizukoshi E, Kitahara M, Arihara F, Sakai Y, Kakinoki K, Fujita Y, Marukawa Y, Arai K, Yamashita T, Mukaida N, Matsushima K, Matsui O, Kaneko S
    • Journal Title

      Clin. Exp.Immunol

      Volume: 163 Pages: 165-177

    • DOI

      10.1111/j.1365-2249.2010.04246.x.

    • Peer Reviewed
  • [Journal Article] Comparative analysis of various tumor-associated antigen-specific t-cell responses in patients with hepatocellular carcinoma2011

    • Author(s)
      Mizukoshi E, Nakamoto Y, Arai K, Yamashita T, Sakai A, Sakai Y, Kagaya T, Yamashita T, Honda M, Kaneko S
    • Journal Title

      HEPATOLOGY

      Volume: 53 Pages: 1206-1216

    • DOI

      10.1002/hep.24149.

    • Peer Reviewed
  • [Journal Article] Frequency of CD45RO+ subset in CD4+CD25(high) regulatory T cells associated with progression of hepatocellular carcinoma2011

    • Author(s)
      Takata Y, Nakamoto Y, Nakada A, Terashima T, Arihara F, Kitahara M, Kakinoki K, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S
    • Journal Title

      Cancer Lett

      Volume: 307 Pages: 165-173

    • DOI

      10.1016/j.canlet.2011.03.029.

    • Peer Reviewed
  • [Journal Article] Hokuriku Liver Study Group : Malnutrition impairs interferon signaling through mTOR and FoxO pathways in patients with chronic hepatitis C2011

    • Author(s)
      Honda M, Takehana K, Sakai A, Tagata Y, Shirasaki T, Nishitani S, Muramatsu T, Yamashita T, Nakamoto Y, Mizukoshi E, Sakai Y, Yamashita T, Nakamura M, Shimakami T, Yi M, Lemon SM, Suzuki T, Wakita T, Kaneko S
    • Journal Title

      GASTROENTEROLOGY

      Volume: 141 Pages: 128-140

    • DOI

      10.1053/j.gastro.2011.03.051.

    • Peer Reviewed
  • [Journal Article] Randomized, phase II study comparing interferon combined with hepatic arterial infusion of fluorouracil plus cisplatin and fluorouracil alone in patients with advanced hepatocellular carcinoma2011

    • Author(s)
      Yamashita T, Arai K, Sunagozaka H, Ueda T, Terashima T, Yamashita T, Mizukoshi E, Sakai A, Nakamoto Y, Honda M, Kaneko S
    • Journal Title

      Oncology

      Volume: 81 Pages: 281-290

    • DOI

      10.1159/000334439.

    • Peer Reviewed
  • [Presentation] Clinical evaluation of patency capsule system in high risk patients for video capsule endoscopy2013

    • Author(s)
      Ohtani M, Suto H, Nakamoto Y
    • Organizer
      Japan Digestive DiseaseWeek 2013
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-10-12
  • [Presentation] MicroRNA Dynamics in Precancerous Lesions in a Mouse Model of Chronic Hepatitis B2012

    • Author(s)
      Nakamoto Y, Yamashita T, Kaneko S
    • Organizer
      第63回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      Boston, Massachusetts, Hepatology 56 (4,Suppl.) 315A
    • Year and Date
      2012-11-13
  • [Presentation] High Incidence of HBV Reactivation after R-CHOP and CHOP Regimens among Patients Treated with Six Immunosuppressive Chemotherapies2012

    • Author(s)
      Naito T, Nemoto T, Matsuda H, Ohtani M, Suto H Nakamoto Y
    • Organizer
      第63回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      Boston, Massachusetts, Hepatology 56 (4,Suppl.) 643A
    • Year and Date
      2012-11-11
  • [Presentation] Differential Dynamics of the NF-kappaB subunits RELA and RELB in a Mouse Model of Chronic Hepatitis B2011

    • Author(s)
      Nakamoto Y, Yamashita T, Kaneko S
    • Organizer
      第62回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      San Francisco, California, Hepatology 54 (4,Suppl.) 1300A
    • Year and Date
      2011-11-08
  • [Presentation] Increase of CD14+HLA-DR-/low myeloid-derived suppressor cells in hepatocellular carcinoma and its impact for prognosis of patients2011

    • Author(s)
      Arihara F, Mizukoshi E, Kitahara M, Takata Y, Arai K, Yamashita T, Nakamoto Y, Kaneko S
    • Organizer
      第62回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      San Francisco, California, Hepatology 54 (4,Suppl.) 1400A
    • Year and Date
      2011-11-08

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Published: 2015-06-25  

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