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2012 Fiscal Year Final Research Report

Determination of cell type(s) that should be transplanted into lesion core of the brain for better outcome

Research Project

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Project/Area Number 23659688
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionEhime University

Principal Investigator

TANAKA Junya  愛媛大学, プロテオ医学研究センター, 教授 (70217040)

Co-Investigator(Kenkyū-buntansha) YANO Hajime  愛媛大学, 大学院・医学系研究科, 准教授 (00284414)
TAKAHASHI Hisaaki  愛媛大学, 医学部附属病院, 講師 (20363228)
SUGIMOTO Kana  愛媛大学, 大学院・医学系研究科, 助教 (00581034)
Co-Investigator(Renkei-kenkyūsha) OHNISHI Takanori  愛媛大学, 大学院・医学系研究科, 教授 (70233210)
KUMON Yoshiaki  愛媛大学, 大学院・医学系研究科, 准教授 (80127894)
Project Period (FY) 2011 – 2012
Keywords脳梗塞 / マイクログリア / 脳損傷 / アストロサイト / 細胞移植 / マクロファージ / 骨髄 / BINCs
Research Abstract

To determine cell type(s) that should be transplanted into the lesion core of ischemic and traumatic brain injuries with an aim to ameliorate the outcomes, several kinds of cultured neural cells including microglial cells, astrocytes, and brain macrophages isolated from ischemic lesion core of rat brains. Consequently,it was found that most of transplanted cells were eliminated by phagocytic macrophages in spite of the isotransplantation. Only BINCs were transplantable into the ischemic core, and their transplantation may be appeared therapeutically effective.

  • Research Products

    (15 results)

All 2013 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (5 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Expression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions2013

    • Author(s)
      Nari Tei, Junya Tanaka, Kana Sugimoto, Tasuku Nishihara, Ryutaro Nishioka, Hisaaki Takahashi, Hajime Yano, Shirabe Matsumoto, Shiro Ohue, Hideaki Watanabe, Yoshiaki Kumon, Takanori Ohnishi
    • Journal Title

      J Neurosci Res

      Volume: 91 Pages: 681-693

    • Peer Reviewed
  • [Journal Article] Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children2012

    • Author(s)
      Hitomi Hino, Hisaaki Takahashi, Yuka Suzuki, Junya Tanaka, Eiichi Ishii, Mitsumasa Fukuda
    • Journal Title

      PLoS ONE

      Volume: 7 Pages: e42920

    • DOI

      DOI:10.1371/journal.pone.0042920

    • Peer Reviewed
  • [Journal Article] Zonisamide up-regulated them RNAs encoding astrocytic anti-oxidative and neurotrophic factors.2012

    • Author(s)
      Choudhury ME, Sugimoto K, Kubo M, Iwaki H, Tsujii T, Kyaw WT, Nishikawa N, Nagai M, Tanaka J, Nomoto M
    • Journal Title

      Eur J Pharmacol

      Volume: 689 Pages: 72-80

    • Peer Reviewed
  • [Journal Article] Premetastatic vasculogenesis in oral squamous cell carcinoma xenograft-draining lymph nodes2012

    • Author(s)
      Mayorca-Guiliani AE, Yano H, Nakashiro KI, Hamakawa H, Tanaka J
    • Journal Title

      Oral Oncology

      Volume: 48 Pages: 663-670

    • Peer Reviewed
  • [Journal Article] Oct-3/4 promotes migration and invasion of glioblastoma cells2012

    • Author(s)
      Kobayashi K, Takahashi H, Inoue A, Harada H, Toshimori S, Kobayashi Y, Goto K, Sugimoto K, Yano H, Ohnishi T, Tanaka J
    • Journal Title

      J Cell Biochem

      Volume: 113 Pages: 508-517

    • Peer Reviewed
  • [Journal Article] Transient ischemia-induced paresis and complete paraplegia displayed distinct reactions of microglia and macrophages2011

    • Author(s)
      NakataT, Kawachi K, Nagashima M, Yasugi T, Izutani H, Ryugo M, Okamura T, Shikata F, Imagawa H, Yano H, Takahashi H, Tanaka J
    • Journal Title

      Brain Res

      Volume: 1420 Pages: 114-124

    • Peer Reviewed
  • [Journal Article] A cytokine mixture of GM‐CSF and IL‐3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6‐OHDA)‐induced Parkinsonism of rats2011

    • Author(s)
      Choudhury ME, Sugimoto K, Kubo M, Nagai M, Nomoto M, Takahashi H, Yano H, Tanaka J
    • Journal Title

      Brain Behav

      Volume: 1 Pages: 26-43

    • Peer Reviewed
  • [Journal Article] Subcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats2011

    • Author(s)
      Nishihara, Michihisa Ochi, Kana Sugimoto, Hisaaki Takahashi, Hajime Yano, Yoshiaki Kumon, Takanori Ohnishi, Junya Tanaka
    • Journal Title

      Exp Neurol

      Volume: 229 Pages: 507-516

    • Peer Reviewed
  • [Presentation] Agents modulating neuroprotective and neurotoxic functions of microglia and their application to the pathologic brains2013

    • Author(s)
      Junya Tanaka
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京都
    • Year and Date
      20130327-29
  • [Presentation] Response of glial cells in and around ischemic lesion of rats that were subjected to transient middle cerebral artery occlusion: the involvement of IL-182013

    • Author(s)
      Ayano Mise, Kana Sugimoto, Ryutaro Nishioka, Hisaaki Takahashi, Hajime Yano, Junya Tanaka
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京都
    • Year and Date
      20130327-29
  • [Presentation] Invasion of monocytes/macrophages into ischemic lesion of rat brain: involvement of chemokines and their receptors2013

    • Author(s)
      Yudai Ohara, Kana Sugimoto, Ryutaro Nishioka, Hisaaki Takahashi, Hajime Yano、Nari Tei, Yoshiaki Kumon, Takanori Ohnishi, Junya Tanaka
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京都
    • Year and Date
      20130327-29
  • [Presentation] A cytokine mixture containing GM-CSF and IL-3 targeting microglia ameliorates neurological deficits of Parkinson's disease model rats2012

    • Author(s)
      Junya Tanaka, Mohammed E. Choudhury, Kana Sugimoto, Hisaaki Takahashi, Hajime Yano
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      大分県由布市
    • Year and Date
      20120803-04
  • [Presentation] 脳梗塞巣に集積するマクロファージの役割とその治療的利用2012

    • Author(s)
      田中潤也、杉本香奈、西原佑、高橋寿明、矢野元
    • Organizer
      第22回日本病態生理学会
    • Place of Presentation
      大分県由布市
    • Year and Date
      20120803-04
  • [Remarks]

    • URL

      http://www.m.ehime-u.ac.jp/school/kisogp/contents/laboratories

  • [Patent(Industrial Property Rights)] 免疫細胞の活性化抑制剤およびその用途2012

    • Inventor(s)
      田中潤也
    • Industrial Property Rights Holder
      国立大学法人愛媛大学
    • Industrial Property Number
      特願2012-173405
    • Filing Date
      2012-08-03

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Published: 2014-08-29   Modified: 2014-10-07  

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