Inhibition of bacterial adhesion on the surface of titanium implant

2011 Fiscal Year Final Research Report

• Project/Area Number: 23659711
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: TANAKA Takeyuki 東京大学, 医学部・附属病院, 助教 (00583121)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Kozo 東京大学, 医学部附属病院, 教授 (60126133) ; ISHIHARA Kazuhiko 東京大学, 大学院・工学系研究科, 教授 (90193341) ; MIURA Toshiki 東京大学, 医学部附属病院, 講師 (20376479) ; ITO Hideya 東京大学, 医学部附属病院, 助教 (30436464) ; KONNO Tomohiro 東京大学, 大学院・工学系研究科, 特任准教授 (80371706)
• Project Period (FY): 2011
• Keywords: 医療・福祉 / 細菌 / ナノ材料

Research Abstract

To inhibit the infection around the implant of artificial joint, we have developed a new technology, surface grafting of a biocompatible polymer for titanium alloy. In addition, we have revealed that biocompatible polymer grafted surface prevented the bacterial adhesion in the experimental infection model. From these results of the study, we believe that this new technology will prevent the infection around the implant of artificial joint.

Research Products

• [Journal Article] Biomimetic hydration lubrication with various polyelectrolyte layers on cross-linked polyethylene orthopedic bearing materials (2012)
  • Author(s): Kyomoto M, Moro T, Saiga K, Hashimoto M, Ito H, Kawaguchi H, Takatori Y, Ishihara K
  • Journal Title: Biomaterials Volume: 33 Pages: 4451-9
  • Peer Reviewed
• [Journal Article] Novel polymer biomaterials and interfaces inspired from cell membrane functions (2011)
  • Author(s): Ishihara K, Goto Y, Matsuno R, Inoue Y, Konno T
  • Journal Title: Biochim Biophys Acta-General Volume: 1810(3) Pages: 268-75
  • Peer Reviewed
• [Journal Article] Adsorption force of proteins against hydrophilic polymer brush surfaces (2011)
  • Author(s): Inoue Y, Nakanishi T, Ishihara K
  • Journal Title: React Funct Polym Volume: 71(3) Pages: 350-5
  • Peer Reviewed
• [Presentation] Evaluation of protein adsorption at polymer brush surfaces based on the water structure surrounding the surface (2012)
  • Author(s): Inoue Y, Ishihara K
  • Organizer: American Chemical Aciety, Spring 2013 National Meeting & Exposition
  • Place of Presentation: San Diego, USA
  • Year and Date: 20120325-29
• [Presentation] Direct evaluation of interaction force between proteins and polymer brush surfaces with well-characterized hydration state (2012)
  • Author(s): Inoue Y, Inoue K, Ishihara K
  • Organizer: 5th International Symposium of Nanomedicine
  • Place of Presentation: Nagoya
  • Year and Date: 20120315-17
• [Presentation] MPCポリマーの基礎と応用 (2011)
  • Author(s): 石原一彦
  • Organizer: 第33回日本バイオマテリアル学会大会
  • Place of Presentation: 京都
  • Year and Date: 20111121-22
• [Presentation] タンパク質吸着に与えるポリマーブラシ表面の水和状態の影響 (2011)
  • Author(s): 井上和臣,井上祐貴,石原一彦
  • Organizer: 第33回日本バイオマテリアル学会大会
  • Place of Presentation: 京都
  • Year and Date: 20111121-22
• [Presentation] 低侵襲医療に役立つ生体親和型ポリマーバイオマテリアル (2011)
  • Author(s): 石原一彦
  • Organizer: 東海ライブ研究会
  • Place of Presentation: 豊橋
  • Year and Date: 20111020-22
• [Presentation] 人工関節金属インプラント表面のMPC処理による細菌付着抑制効果の検討 (2011)
  • Author(s): 茂呂徹,高取吉雄,石原一彦,京本政之,安藤嘉基,宮本比呂志,伊藤英也,角田俊治,田中健之,大嶋浩文,中村耕三,川口浩
  • Organizer: 第36回日本整形外科学会基礎学術集会
  • Place of Presentation: 前橋
  • Year and Date: 20111020-21
• [Presentation] Biomimetic surface modification on artificial hip joint for elongation of implantation life (2011)
  • Author(s): Ishihara K, Kyomoto M, Moro T, Takatori Y
  • Organizer: European Society for Artificial Organs(ESAO)
  • Place of Presentation: Porto, Portugal
  • Year and Date: 20111009-12
• [Presentation] 未来を拓くナノ医療とは?-新しい医療原則の確立と価値の創出 (2011)
  • Author(s): 石原一彦,山岡哲二
  • Organizer: 第60回高分子討論会
  • Place of Presentation: 岡山
  • Year and Date: 20110928-30
• [Presentation] タンパク質吸着を支配するポリマーブラシ表面近傍の水和状態 (2011)
  • Author(s): 井上祐貴,井上和臣,石原一彦
  • Organizer: 第60回高分子討論会
  • Place of Presentation: 岡山
  • Year and Date: 20110928-30
• [Presentation] 生体親和性ポリマーブラシ表面でのタンパク質との相互作用力のナノ解析 (2011)
  • Author(s): 坂田翔,井上祐貴,石原一彦
  • Organizer: 第60回高分子討論会
  • Place of Presentation: 岡山
  • Year and Date: 20110928-30
• [Presentation] Importance of dynamics of water molecules on protein adsorption at polymer brush surfaces (2011)
  • Author(s): Inoue K, Inoue Y, Ishihara K
  • Organizer: The 3rd Asian Biomaterials Congress
  • Place of Presentation: Busan, Korea
  • Year and Date: 20110915-17
• [Presentation] Highly biocompatible surface for implatable artificial organ (2011)
  • Author(s): Ishihara K
  • Organizer: The 3rd Asian Biomaterials Congress
  • Place of Presentation: Busan, Korea
  • Year and Date: 20110915-17
• [Presentation] Surface modification withphospholipid polymers for long-term implantable medical devices (2011)
  • Author(s): Ishihara K, Kyomoto M, Moro T, Inoue Y
  • Organizer: THERMEC' 2011
  • Place of Presentation: Quebec, Canada
  • Year and Date: 20110801-05
• [Presentation] MPCポリマーの表面処理による人工関節金属表面の細菌付着抑制効果 (2011)
  • Author(s): 茂呂徹,高取吉雄,中村耕三,石原一彦,京本政之,安藤嘉基,宮本比呂志,伊藤英也,角田俊治,田中健之,大嶋浩文,雑賀健一,川口浩
  • Organizer: 第34回日本骨・感染症学会
  • Place of Presentation: 淡路島
  • Year and Date: 20110708-11
• [Presentation] ブロックコポリマーの自己組織化相分離構造による細胞接着性の制御 (2011)
  • Author(s): 柴山崇, Seo Ji-Hun,石原一彦,高井まどか
  • Organizer: 第23回化学とマイクロ・ナノシステム研究会
  • Place of Presentation: 千葉
  • Year and Date: 20110610-11
• [Presentation] ナノバイオマテリアル・インテグレーションと未来医学 (2011)
  • Author(s): 石原一彦
  • Organizer: ナノ学会第9回大会
  • Place of Presentation: 札幌
  • Year and Date: 20110602-04
• [Presentation] タンパク質吸着過程のナノ解析による生体親和型ポリマー表面の設計 (2011)
  • Author(s): 井上祐貴,中西智亮,石原一彦
  • Organizer: 第60回高分子学会年次大会
  • Place of Presentation: 大阪
  • Year and Date: 20110525-27
• [Presentation] タンパク質吸着に与えるポリマーブラシ表面の水和状態の効果 (2011)
  • Author(s): 井上和臣,井上祐貴,石原一彦
  • Organizer: 第60回高分子学会年次大会
  • Place of Presentation: 大阪
  • Year and Date: 20110525-27
• [Presentation] High oxidation-and wear-resistance of PMPC-grafted polyethylene arisen by extra plasma irradiation (2011)
  • Author(s): Kyomoto M, Moro T, Saiga K, Takatori Y, Ishihara K
  • Organizer: 2011 Annual Meeting & Exposition of the Society for Biomaterials(SFB)
  • Place of Presentation: Orlando, USA
  • Year and Date: 20110413-16
• [Presentation] Inhibition of inflammatory responses on phospholipid polymer-coated nanoparticles (2011)
  • Author(s): Ishihara K, Goto Y, Matsuno R, Inoue Y, Konno T, Takai M
  • Organizer: 2011 Annual Meeting & Exposition of the Society for Biomaterials(SFB)
  • Place of Presentation: Orlando, USA
  • Year and Date: 20110413-16
• [Presentation] Cytocompatible polymer surface with photocleavable groups for regulating the single cell attachment/detachment (2011)
  • Author(s): Byambaa B, Konno T, Ishihara K
  • Organizer: 2011 Annual Meeting & Exposition of the Society for Biomaterials(SFB)
  • Place of Presentation: Orlando, USA
  • Year and Date: 20110413-16
• [Presentation] Elucidation of protein adsorption behavior based on molecular dynamics around polymer brush surface (2011)
  • Author(s): Inoue Y, Nakanishi T, Ishihara K
  • Organizer: 2011 Annual Meeting & Exposition of the Society for Biomaterials(SFB)
  • Place of Presentation: Orlando, USA
  • Year and Date: 20110413-16
• [Presentation] 日本発の高性能ポリマーバイオマテリアルMPCポリマーの創発と応用 (2011)
  • Author(s): 石原一彦
  • Organizer: 医療機器フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2011-10-03