2012 Fiscal Year Final Research Report
Involvement of Toll-like receptors in the Actions of Opioids
| Project/Area Number |
23659742
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | オピオイド / モルヒネ / 耐性 / マイクログリア / ノックアウトマウス |
|---|
| Research Abstract |
To examine the hypothesis that the toll-like receptor 4 (TLR4) is involved in the morphine-induced activation of microglia, we analyzed morphine tolerance in TLR4 knockout mice and C3H/HeJ mice possessing mutated TLR4. It was shown that morphine tolerance was induced in both knockout and mutant mice similarly as wild-type mice, and suggested that TLR4 is not involved in morphine-induced activation of microglia. Our results suggest that morphine tolerance is mediated by microglia activated through the mechanism other than TLR4.
|
