2012 Fiscal Year Final Research Report
Metabolomic approach to metabolic biology of cancer cells
| Project/Area Number |
23659866
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ECHIGO Seishi 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (70005114)
WASHIO Jumpei 東北大学, 大学院・歯学研究科, 助教 (20400260)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 癌組織 / メタボローム解析 / 糖代謝 / アミノ酸代謝 |
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| Research Abstract |
Metabolome analyses of oral squamous cancer (OSC) were performed by CE-TOFMS, targeting metabolites of Embden-Meyerhof-Parnas pathway (EMPP),pentose-phosphate pathway, TCA cycle and metabolic pathways for amino acids. Method for metabolome analyses of OSC was established. The results suggest that the enhancement of EMPP (Warburg effect) occurred in OSC, as previously reported for other cancers, and that amino acids such as glutamine were utilized as an additional energy source for OSC.
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[Journal Article] Rapid quantification of bacteria ininfected root canals using fluorescence filter - A pilot study on its clinical application to the evaluation of the outcomes of endodontic treatment -2012
Author(s)
Sato T, Yamaki K, Ishida N, Shoji M, Sato E, Abiko Y, Hashimoto K, Takeuchi Y, Matsuyama J, Shimauchi H, Takahashi N
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Journal Title
DOI
Peer Reviewed
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[Presentation] バイオマテリアル-パラサイト・インターフェイスへの挑戦-バイオマテリアルの生物学的劣化の理解へ-2012
Author(s)
高橋信博,真柳弦,中條和子,鷲尾純平,佐藤拓一,竹内裕尚,佐久間陽子,松尾洋,末永華子,鈴木治,佐々木啓一
Organizer
九州大学応用力学研究所平成23年度共同利用研究集会「力学適応能、自己組織化能を有するバイオマテリアル-生体インターフェイスの創製」(招待講演)
Place of Presentation
福岡
Year and Date
2012-03-02
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