2013 Fiscal Year Final Research Report
Retinal neuroprotection by transscleral multi-drug delivery
| Project/Area Number |
23680054
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tohoku University |
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Principal Investigator |
NAGAI Nobuhiro 東北大学, 医学(系)研究科(研究院), 助教 (30400039)
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| Co-Investigator(Renkei-kenkyūsha) |
ABE Toshiaki 東北大学, 大学院医学系研究科, 教授 (90191858)
KAJI Hirokazu 東北大学, 大学院工学研究科, 准教授 (70431525)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 薬物伝達システム |
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| Research Abstract |
We develped a polymeric device for multi-drug transscleral-delivery to the retina at independently controlled release rates. The device comprises a microfabricated reservoir, controlled-release cover, and drug formulations, which were made of photopolymeized tri(ethyleneglycol)dimethacrylate (TEGDM) and poly(ethyleneglycol)dimethacrylate (PEGDM). The release rate of each drug is controlled by varying the PEGDM/TEGDM ratio in its formulation. When the devices containing three different fluorescents were implanted onto rat sclerae, fluorescence was observable in the ocular tissues during 4 weeks implantation. The device when simultaneously releasing two drugs, edaravone (EDV) and unoprostone (UNO), with controlled release manner precluded the reductions of electroretinographic amplitudes, retinal thickness, and the number of apoptotic cells after light exposure in rats, suggesting that co-delivery of EDV and UNO attenuates light-induced retinal damage morphologically and functionally.
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[Journal Article] A Platform for Controlled Dual-Drug Delivery to the Retina : Protective Effects against Light-Induced Retinal Damage in Rats2014
Author(s)
N Nagai, H Kaji, H Onami, Y Katsukura, Y Ishikawa, ZK Nezhad, K Sampei, S Iwata, S Ito, M Nishizawa, T Nakazawa, N Osumi, Y Mashima, T Abe
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Journal Title
Advanced Healthcare Materials
DOI
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[Presentation] Protective Effects of Transscleral Drug Delivery Device Against Photoreceptor Cell Death in S334ter Rhodopsin Mutant Rats2013
Author(s)
N Nagai, H Kaji, H Onami, T Yamada, Y Katsukura, Y Ishikawa, M Nishizawa, Y Mashima, T Abe
Organizer
2013 ARVO annual meeting, Seattle
Place of Presentation
Washington, USA
Year and Date
20130505-09
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[Presentation] Protective Effects of Transscleral Drug Delivery Device Against Light-induced Retinal Damage in Rats2012
Author(s)
N Nagai, H Onami, H Kaji, T Yamada, Y Katsukura, M Sato, Y Ishikawa, T Nakazawa, M Nishizawa, T Abe
Organizer
2012 ARVO annual meeting
Place of Presentation
Fort Lauderdale, Florida, USA
Year and Date
20120506-10
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[Presentation] Suppression of Rat Choroidal Neovascularization by Transscleral Vasohibin-1 Delivery Device2012
Author(s)
H Onami, N Nagai, R Wakusawa , H Kaji, T Yamada, Y Ishikawa, M Nishizawa, Y Sato, T Nakazawa, T Abe
Organizer
2012 ARVO annual meeting
Place of Presentation
Fort Lauderdale, Florida, USA
Year and Date
20120506-10
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